FA Cup 2023/24, Preliminary Round |
 | 18.08.2023 |  | Skelmersdale United | – | Nantwich Town | | 0:6 (0:3) |
| Skelmersdale |
FA Cup 2022/23, Preliminary Round |
| 20.08.2022 | | Skelmersdale United | – | Prescot Cables | | 1:3 (0:3) |
| Skelmersdale |
FA Cup 2021/22, First Qualifying Round |
| 04.09.2021 | | Radcliffe | – | Skelmersdale United | | 2:0 (1:0) |
| Radcliffe |
FA Cup 2020/21, First Round Proper |
| 06.11.2020 | | Harrogate Town | – | Skelmersdale United | | 4:1 (2:0) * |
| Harrogate |
FA Cup 2019/20, Preliminary Round |
| 24.08.2019 | | City of Liverpool | – | Skelmersdale United | | 2:1 (1:0) |
| Liverpool |
FA Cup 2018/19, Preliminary Round |
| 25.08.2018 | | Ashton Athletic | – | Skelmersdale United | | 2:1 (0:0) |
| Ashton-in-Makerfield |
FA Cup 2017/18, First Qualifying Round |
| 02.09.2017 | | Skelmersdale United | – | Handsworth Parramore | | 1:2 (1:1) |
| Skelmersdale |
FA Cup 2016/17, First Qualifying Round |
| 06.09.2016 | | Skelmersdale United | – | Dunston UTS | | 1:2 * |
| Skelmersdale |
FA Cup 2015/16, Second Qualifying Round |
| 26.09.2015 | | Bamber Bridge | – | Skelmersdale United | | 2:0 (0:0) |
| Bamber Bridge |
FA Cup 2014/15, Second Qualifying Round |
| 27.09.2014 | | Skelmersdale United | – | Blyth Spartans | | 1:4 (1:1) |
| Skelmersdale |
FA Cup 2013/14, Second Qualifying Round |
| 28.09.2013 | | West Auckland Town | – | Skelmersdale United | | 5:0 |
| West Auckland |
FA Cup 2012/13, Second Qualifying Round |
| 22.09.2012 | | Tadcaster Albion | – | Skelmersdale United | | 4:1 (2:1) |
| Tadcaster |
FA Cup 2011/12, Preliminary Round |
| 03.09.2011 | | Clitheroe | – | Skelmersdale United | | 4:0 |
| |
FA Cup 2010/11, Second Qualifying Round |
| 25.09.2010 | | Shildon | – | Skelmersdale United | | 2:0 |
| |
FA Cup 2009/10, Preliminary Round |
| 29.08.2009 | | Salford City | – | Skelmersdale United | | 3:2 |
| |
FA Cup 2008/09, First Qualifying Round |
| 13.09.2008 | | Frickley Athletic | – | Skelmersdale United | | 1:0 |
| |
FA Cup 2007/08, Second Qualifying Round |
| 29.09.2007 | | Skelmersdale United | – | Southport | | 0:1 |
| |
FA Cup 2006/07, Third Qualifying Round |
| 14.10.2006 | | Droylsden | – | Skelmersdale United | | 3:2 |
| |
FA Cup 2005/06, Third Qualifying Round |
| 08.10.2005 | | Vauxhall Motors | – | Skelmersdale United | | 4:3 |
| |
FA Cup 2004/05, Second Qualifying Round |
| | | Skelmersdale United | – | Burscough | | 2:3 |
| |
FA Cup 2003/04, Second Qualifying Round |
| | | Gainsborough Trinity | – | Skelmersdale United | | 6:0 |
| |
FA Cup 2002/03, Preliminary Round |
| | | Skelmersdale United | – | Penrith | | 1:3 |
| |
FA Cup 2001/02, First Qualifying Round |
| | | Ashton United | – | Skelmersdale United | | 4:2 |
| |
FA Cup 2000/01, Preliminary Round |
| | | Guiseley | – | Skelmersdale United | | 4:0 * |
| |
FA Cup 1999/00, First Qualifying Round |
| | | Bradford Park Avenue | – | Skelmersdale United | | 2:1 |
| |
FA Cup 1998/99, First Qualifying Round |
| | | Morpeth Town | – | Skelmersdale United | | 2:0 |
| |
FA Cup 1997/98, First Qualifying Round |
| | | South Shields | – | Skelmersdale United | | 3:0 |
| |
FA Cup 1994/95, First Qualifying Round |
| | | Skelmersdale United | – | Frickley Athletic | | 1:4 * |
| |
FA Cup 1993/94, Preliminary Round |
| | | Skelmersdale United | – | Thackley | | 0:1 |
| |
FA Cup 1992/93, Preliminary Round |
| | | Warrington Town | – | Skelmersdale United | | 6:1 |
| |
FA Cup 1991/92, First Qualifying Round |
| | | Skelmersdale United | – | Macclesfield Town | | 0:4 |
| |
FA Cup 1990/91, Preliminary Round |
| | | Skelmersdale United | – | Glossop | | 0:2 * |
| |
FA Cup 1989/90, Preliminary Round |
| | | Curzon Ashton | – | Skelmersdale United | | 2:0 * |
| |
FA Cup 1988/89, First Qualifying Round |
| | | Skelmersdale United | – | Morecambe | | 1:2 * |
| |
FA Cup 1987/88, Preliminary Round |
| | | Skelmersdale United | – | Radcliffe Borough | | 0:1 |
| |
FA Cup 1986/87, Third Qualifying Round |
| | | Skelmersdale United | – | Northwich Victoria | | 2:3 |
| |
FA Cup 1985/86, First Qualifying Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 3:0 * |
| |
FA Cup 1984/85, First Qualifying Round |
| | | Burscough | – | Skelmersdale United | | 3:0 |
| |
FA Cup 1982/83, Preliminary Round |
| | | Skelmersdale United | – | Prestwich Heys | | 0:4 |
| |
FA Cup 1981/82, Preliminary Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 4:0 |
| |
FA Cup 1980/81, First Qualifying Round |
| | | Skelmersdale United | – | Chorley | | 0:1 |
| |
FA Cup 1979/80, First Qualifying Round |
| | | Skelmersdale United | – | Lancaster City | | 1:4 |
| |
FA Cup 1978/79, First Qualifying Round |
| | | Skelmersdale United | – | Hyde United | | 0:1 * |
| |
FA Cup 1977/78, Preliminary Round |
| | | Skelmersdale United | – | Accrington Stanley | | 0:3 |
| |
FA Cup 1976/77, Preliminary Round |
| | | Skelmersdale United | – | New Brighton | | 0:2 * |
| |
FA Cup 1975/76, Second Qualifying Round |
| | | Chorley | – | Skelmersdale United | | 3:1 |
| |
FA Cup 1974/75, Second Qualifying Round |
| | | Sandbach Ramblers | – | Skelmersdale United | | 2:1 |
| |
FA Cup 1973/74, First Qualifying Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 3:1 |
| |
FA Cup 1972/73, Fourth Qualifying Round |
| | | Skelmersdale United | – | Rhyl |  | 0:4 |
| |
FA Cup 1971/72, First Round Proper |
| 20.11.1971 | | Skelmersdale United | – | Tranmere Rovers | | 0:4 |
| |
FA Cup 1970/71, Fourth Qualifying Round |
| | | Wigan Athletic | – | Skelmersdale United | | 5:0 * |
| |
FA Cup 1969/70, Fourth Qualifying Round |
| | | Wigan Athletic | – | Skelmersdale United | | 2:0 |
| |
FA Cup 1968/69, First Round Proper |
| 16.11.1968 | | Chesterfield | – | Skelmersdale United | | 2:0 |
| |
FA Cup 1967/68, First Round Proper |
| 09.12.1967 | | Scunthorpe United | – | Skelmersdale United | | 2:0 |
| |
FA Cup 1966/67, Third Qualifying Round |
| | | Rhyl | – | Skelmersdale United | | 2:0 |
| |
FA Cup 1965/66, Third Qualifying Round |
| | | Altrincham | – | Skelmersdale United | | 4:1 |
| |
FA Cup 1964/65, Second Qualifying Round |
| | | South Liverpool | – | Skelmersdale United | | 5:3 * |
| |
FA Cup 1963/64, Second Qualifying Round |
| | | Skelmersdale United | – | Altrincham | | 0:3 |
| |
FA Cup 1962/63, First Qualifying Round |
| | | South Liverpool | – | Skelmersdale United | | 3:1 |
| |
FA Cup 1961/62, First Qualifying Round |
| | | Skelmersdale United | – | Wigan Athletic | | 0:4 |
| |
FA Cup 1960/61, Third Qualifying Round |
| | | Wigan Athletic | – | Skelmersdale United | | 2:1 * |
| |
FA Cup 1959/60, Preliminary Round |
| | | Mossley | – | Skelmersdale United | | 3:0 * |
| |
FA Cup 1958/59, Third Qualifying Round |
| | | Chorley | – | Skelmersdale United | | 3:0 * |
| |
FA Cup 1957/58, Preliminary Round |
| | | Ashton United | – | Skelmersdale United | | 3:1 |
| |
FA Cup 1956/57, First Qualifying Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 2:1 |
| |
FA Cup 1955/56, Preliminary Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 3:2 |
| |
FA Cup 1954/55, Preliminary Round |
| | | Horwich Railway Mechanics Institute | – | Skelmersdale United | | 1:0 |
| |
FA Cup 1953/54, Third Qualifying Round |
| | | Skelmersdale United | – | Mossley | | 1:3 |
| |
FA Cup 1952/53, First Qualifying Round |
| | | Ashton United | – | Skelmersdale United | | 7:2 |
| |
FA Cup 1951/52, Fourth Qualifying Round |
| | | Skelmersdale United | – | Nelson | | 0:3 |
| |
FA Cup 1950/51, Second Qualifying Round |
| | | Burscough | – | Skelmersdale United | | 3:2 |
| |
FA Cup 1949/50, Preliminary Round |
| | | Prescot Cables | – | Skelmersdale United | | 3:0 |
| |
FA Cup 1948/49, Preliminary Round |
| | | Wigan Athletic | – | Skelmersdale United | | 2:1 |
| |
FA Cup 1947/48, Second Qualifying Round |
| | | Skelmersdale United | – | Prescot Cables | | 0:3 * |
| |
FA Cup 1946/47, Third Qualifying Round |
| | | Darwen | – | Skelmersdale United | | 6:4 * |
| |
FA Cup 1945/46, Second Qualifying Round |
| | | Skelmersdale United | – | Darwen | | 2:3 * |
| |
