FA Cup 2021/22, Third qualifying round |
 | 05.10.2021 |  | Southport | – | Spennymoor Town | | 3:2 (1:2) * |
| Southport |
FA Cup 2021/22, Second qualifying round |
| 21.09.2021 | | Southport | – | Chorley | | 1:0 (1:0) * |
| Southport |
FA Cup 2020/21, Second Qualifying Round |
| 03.10.2020 | | Southport | – | Morpeth Town | | 2:1 |
| Southport |
FA Cup 2019/20, Third Qualifying Round |
| 05.10.2019 | | Farsley Celtic | – | Southport | | 0:5 (0:1) |
| Farsley |
FA Cup 2019/20, Second Qualifying Round |
| 21.09.2019 | | Southport | – | Scarborough Athletic | | 5:2 (2:1) |
| Southport |
FA Cup 2018/19, First Round Proper |
| 10.11.2018 | | Southport | – | Boreham Wood | | 2:0 (1:0) |
| Southport |
FA Cup 2018/19, Fourth Qualifying Round |
| 20.10.2018 | | Southport | – | Ashton United | | 2:1 (1:0) |
| Southport |
FA Cup 2018/19, Third Qualifying Round |
| 06.10.2018 | | Curzon Ashton | – | Southport | | 1:2 (0:1) |
| Ashton-under-Lyne |
FA Cup 2018/19, Second Qualifying Round |
| 22.09.2018 | | Farsley Celtic | – | Southport | | 0:3 (0:0) |
| Farsley |
FA Cup 2016/17, Fourth Qualifying Round |
| 15.10.2016 | | Southport | – | Chester | | 1:0 (1:0) |
| Southport |
FA Cup 2014/15, Second Round Proper |
| 07.12.2014 | | Southport | – | Eastleigh | | 2:1 (1:1) |
| Southport |
FA Cup 2014/15, First Round Proper |
| 18.11.2014 | | Southport | – | Dagenham & Redbridge | | 2:0 (0:0) * |
| Southport |
FA Cup 2013/14, Fourth Qualifying Round |
| 26.10.2013 | | Southport | – | Marske United | | 6:2 (5:1) |
| Southport |
FA Cup 2011/12, Fourth Qualifying Round |
| 29.10.2011 | | Southport | – | Stockport County | | 1:0 (1:0) |
| Southport |
FA Cup 2010/11, Fourth Qualifying Round |
| 23.10.2010 |  | Wrexham | – | Southport | | 1:2 |
| Wrexham |
FA Cup 2009/10, Third Qualifying Round |
| 13.10.2009 | | Southport | – | Alfreton Town | | 2:1 * |
| |
FA Cup 2009/10, Second Qualifying Round |
| 26.09.2009 | | Southport | – | Spennymoor Town | | 3:1 |
| |
FA Cup 2008/09, Second Qualifying Round |
| 27.09.2008 | | Southport | – | Vauxhall Motors | | 3:2 |
| |
FA Cup 2007/08, Third Qualifying Round |
| 13.10.2007 | | Belper Town | – | Southport | | 0:3 |
| |
FA Cup 2007/08, Second Qualifying Round |
| 29.09.2007 | | Skelmersdale United | – | Southport | | 0:1 |
| |
FA Cup 2005/06, Fourth Qualifying Round |
| 22.10.2005 | | Southport | – | Kidderminster Harriers | | 1:0 (0:0) |
| Southport |
FA Cup 2004/05, Fourth Qualifying Round |
| | | Southport | – | Hyde United | | 3:1 (3:1) |
| |
FA Cup 2004/05, Third Qualifying Round |
| | | Stratford Town | – | Southport | | 0:3 |
| |
FA Cup 2004/05, Second Qualifying Round |
| | | Ramsbottom United | – | Southport | | 0:2 |
| |
FA Cup 2002/03, First Round Proper |
| 16.11.2002 | | Southport | – | Notts County | | 4:2 (1:2) |
| Southport |
FA Cup 2002/03, Fourth Qualifying Round |
| | | Southport | – | Bridlington Town | | 4:1 (1:1) |
| |
FA Cup 2001/02, Fourth Qualifying Round |
| | | Southport | – | Marine | | 2:1 (1:0) * |
| |
FA Cup 2000/01, First Round Proper |
| 18.11.2000 | | Havant & Waterlooville | – | Southport | | 1:2 (1:1) |
| Havant |
FA Cup 2000/01, Fourth Qualifying Round |
| | | Southport | – | Doncaster Rovers | | 1:0 (1:0) * |
| |
FA Cup 1999/00, Fourth Qualifying Round |
| | | Emley | – | Southport | | 0:2 (0:0) * |
| |
FA Cup 1998/99, Second Round Proper |
| 05.12.1998 | | Mansfield Town | – | Southport | | 1:2 (0:1) |
| Mansfield |
FA Cup 1998/99, First Round Proper |
| 14.11.1998 | | Dulwich Hamlet | – | Southport | | 0:1 (0:0) |
| |
FA Cup 1998/99, Fourth Qualifying Round |
| | | Southport | – | Stourbridge | | 4:0 |
| |
FA Cup 1998/99, Third Qualifying Round |
| | | Ramsbottom United | – | Southport | | 0:5 |
| |
FA Cup 1997/98, Fourth Qualifying Round |
| | | Southport | – | North Ferriby United | | 2:0 |
| |
FA Cup 1996/97, Fourth Qualifying Round |
| | | Southport | – | Spennymoor United | | 2:1 * |
| |
FA Cup 1996/97, Third Qualifying Round |
| | | Southport | – | Burton Albion | | 4:1 |
| |
FA Cup 1996/97, Second Qualifying Round |
| | | Emley | – | Southport | | 2:3 * |
| |
FA Cup 1996/97, First Qualifying Round |
| | | Rossendale United | – | Southport | | 0:5 |
| |
FA Cup 1994/95, Fourth Qualifying Round |
| | | Southport | – | Stalybridge Celtic | | 2:1 |
| |
FA Cup 1992/93, First Round Proper |
| 14.11.1992 | | Blyth Spartans | – | Southport | | 1:2 (1:1) |
| Blyth |
FA Cup 1992/93, Fourth Qualifying Round |
| | | Southport | – | Barrow | | 3:2 * |
| |
FA Cup 1992/93, Third Qualifying Round |
| | | Brigg Town | – | Southport | | 0:1 |
| |
FA Cup 1992/93, Second Qualifying Round |
| | | Southport | – | Chadderton | | 2:0 |
| |
FA Cup 1992/93, First Qualifying Round |
| | | Buxton | – | Southport | | 1:2 * |
| |
FA Cup 1991/92, First Qualifying Round |
| | | Ossett Town | – | Southport | | 0:1 |
| |
FA Cup 1990/91, First Qualifying Round |
| | | Armthorpe Welfare | – | Southport | | 1:2 |
| |
FA Cup 1989/90, Third Qualifying Round |
| | | Rhyl | – | Southport | | 0:3 |
| |
FA Cup 1989/90, Second Qualifying Round |
| | | Southport | – | Arnold Town | | 2:1 |
| |
FA Cup 1989/90, First Qualifying Round |
| | | Southport | – | Stalybridge Celtic | | 3:2 |
| |
FA Cup 1988/89, Fourth Qualifying Round |
| | | Southport | – | Tow Law Town | | 2:1 |
| |
FA Cup 1988/89, Third Qualifying Round |
| | | Southport | – | Bangor City | | 3:0 |
| |
FA Cup 1988/89, Second Qualifying Round |
| | | Southport | – | Harworth Colliery Institute | | 2:0 |
| |
FA Cup 1988/89, First Qualifying Round |
| | | Southport | – | Penrith | | 1:0 |
| |
FA Cup 1986/87, Fourth Qualifying Round |
| | | Macclesfield Town | – | Southport | | 0:1 |
| |
FA Cup 1986/87, Third Qualifying Round |
| | | Southport | – | Emley | | 2:0 * |
| |
FA Cup 1986/87, Second Qualifying Round |
| | | Southport | – | Lancaster City | | 3:1 * |
| |
FA Cup 1986/87, First Qualifying Round |
| | | Southport | – | Garforth Town | | 2:1 * |
| |
FA Cup 1985/86, Second Qualifying Round |
| | | Southport | – | Stalybridge Celtic | | 2:0 |
| |
FA Cup 1985/86, First Qualifying Round |
| | | Southport | – | Clitheroe | | 4:2 |
| |
FA Cup 1984/85, First Qualifying Round |
| | | Leyland Motors | – | Southport | | 0:4 |
| |
FA Cup 1983/84, Second Qualifying Round |
| | | Prestwich Heys | – | Southport | | 0:1 |
| |
FA Cup 1983/84, First Qualifying Round |
| | | Radcliffe Borough | – | Southport | | 1:3 |
| |
FA Cup 1982/83, Preliminary Round |
| | | Lytham | – | Southport | | 1:2 |
| |
FA Cup 1978/79, Fourth Qualifying Round |
| | | Southport | – | Northwich Victoria | | 2:0 * |
| |
FA Cup 1968/69, First Round Proper |
| 16.11.1968 | | Tranmere Rovers | – | Southport | | 0:1 |
| |
FA Cup 1967/68, Second Round Proper |
| 06.01.1968 | | Southport | – | Runcorn | | 4:2 |
| |
FA Cup 1967/68, First Round Proper |
| 09.12.1967 | | Southport | – | Lincoln City | | 3:1 |
| |
FA Cup 1965/66, Fourth Round Proper |
| 12.02.1966 | | Southport | – | Cardiff City | | 2:0 |
| |
FA Cup 1965/66, Third Round Proper |
| 25.01.1966 | | Ipswich Town | – | Southport | | 2:3 * |
| |
FA Cup 1965/66, Second Round Proper |
| 13.12.1965 | | Stockport County | – | Southport | | 0:2 * |
| |
FA Cup 1965/66, First Round Proper |
| 13.11.1965 | | Southport | – | Halifax Town | | 2:0 |
| |
FA Cup 1964/65, Second Round Proper |
| 05.12.1964 | | Wrexham | – | Southport | | 2:3 |
| |
FA Cup 1964/65, First Round Proper |
| 14.11.1964 | | Southport | – | Annfield Plain | | 6:1 |
| |
FA Cup 1963/64, First Round Proper |
| 16.11.1963 | | Southport | – | Walsall | | 2:1 |
| |
FA Cup 1961/62, Second Round Proper |
| 25.11.1961 | | Southport | – | Mansfield Town | | 4:2 |
| |
FA Cup 1961/62, First Round Proper |
| 04.11.1961 | | Southport | – | Northwich Victoria | | 1:0 |
| |
FA Cup 1960/61, Second Round Proper |
| 29.11.1960 | | Southport | – | Bangor City | | 3:1 * |
| |
FA Cup 1960/61, First Round Proper |
| 05.11.1960 | | Southport | – | Macclesfield Town | | 7:2 |
| |
FA Cup 1955/56, First Round Proper |
| 19.11.1955 | | Southport | – | Ashton United | | 6:1 |
| |
FA Cup 1953/54, First Round Proper |
| 21.11.1953 | | Southport | – | Carlisle United | | 1:0 |
| |
FA Cup 1952/53, First Round Proper |
| 22.11.1952 | | Southport | – | Bangor City | | 3:1 |
| |
FA Cup 1951/52, First Round Proper |
| 27.11.1951 | | Southport | – | Bangor City | | 3:0 * |
| |
FA Cup 1950/51, First Round Proper |
| 28.11.1950 | | Southport | – | Lincoln City | | 3:2 * |
| |
FA Cup 1949/50, Second Round Proper |
| 10.12.1949 | | Southport | – | Bradford City | | 2:1 |
| |
FA Cup 1949/50, First Round Proper |
| 01.12.1949 | | Barrow | – | Southport | | 0:1 * |
| |
FA Cup 1948/49, Second Round Proper |
| 18.12.1948 | | York City | – | Southport | | 0:2 * |
| |
FA Cup 1948/49, First Round Proper |
| 27.11.1948 | | Southport | – | Horden Colliery Welfare | | 2:1 |
| |
FA Cup 1938/39, Second Round Proper |
| 10.12.1938 | | Southport | – | Swindon Town | | 2:0 |
| |
FA Cup 1938/39, First Round Proper |
| 29.11.1938 | | Southport | – | Scarborough | | 5:3 * |
| |
FA Cup 1936/37, First Round Proper |
| 28.11.1936 | | Frickley Colliery | – | Southport | | 0:2 |
| |
FA Cup 1932/33, First Round Proper |
| 29.11.1932 | | Nelson | – | Southport | | 0:4 * |
| |
FA Cup 1931/32, Third Round Proper |
| 12.01.1932 | | Southport | – | Barnsley | | 4:1 * |
| |
FA Cup 1930/31, Fifth Round Proper |
| 14.02.1931 | | Southport | – | Bradford Park Avenue | | 1:0 |
| |
FA Cup 1930/31, Fourth Round Proper |
| 24.01.1931 | | Southport | – | Blackpool | | 2:1 |
| |
FA Cup 1930/31, Third Round Proper |
| 10.01.1931 | | Southport | – | Millwall | | 3:1 |
| |
FA Cup 1930/31, Second Round Proper |
| 13.12.1930 | | Gainsborough Trinity | – | Southport | | 0:4 |
| |
FA Cup 1930/31, First Round Proper |
| 29.11.1930 | | Southport | – | Darlington | | 4:2 |
| |
FA Cup 1928/29, First Round Proper |
| 24.11.1928 | | Annfield Plain | – | Southport | | 1:4 |
| |
FA Cup 1927/28, Third Round Proper |
| 14.01.1928 | | Southport | – | Fulham | | 3:0 |
| |
FA Cup 1927/28, Second Round Proper |
| 10.12.1927 | | Bradford Park Avenue | – | Southport | | 0:2 |
| |
FA Cup 1927/28, First Round Proper |
| 26.11.1927 | | Denaby United | – | Southport | | 2:3 |
| |
FA Cup 1926/27, Third Round Proper |
| 08.01.1927 | | Southport | – | Blackburn Rovers | | 2:0 |
| |
FA Cup 1926/27, Second Round Proper |
| 11.12.1926 | | Southport | – | Crook Town | | 2:0 |
| |
FA Cup 1926/27, First Round Proper |
| 02.12.1926 | | Tranmere Rovers | – | Southport | | 1:2 * |
| |
FA Cup 1925/26, Second Round Proper |
| 12.12.1925 | | Durham City | – | Southport | | 0:3 |
| |
FA Cup 1925/26, First Round Proper |
| 28.11.1925 | | Southport | – | Mold | | 1:0 |
| |
FA Cup 1884/85, Second Round |
| 22.11.1884 | | Southport Central | – | Clitheroe Low Moor | | 3:1 |
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