Copa Libertadores 2024, First Round |
 | 06.02.2024 |  | Academia | – | Defensor Sporting |  | 3:2 (2:1) |
| Valencia |
Copa Libertadores 2019, Third qualifying stage |
| 20.02.2019 | | Defensor Sporting | – | Atlético Mineiro |  | 0:2 (0:1) |
| Montevideo |
Copa Libertadores 2019, Second qualifying stage |
| 12.02.2019 |  | Barcelona | – | Defensor Sporting | | 1:0 (1:0) |
| Guayaquil |
Copa Libertadores 2019, First qualifying stage |
| 30.01.2019 | | Defensor Sporting | – | Bolívar |  | 2:3 (1:3) |
| Montevideo |
Copa Libertadores 2018, Group 1 |
| 23.05.2018 | | Grêmio | – | Defensor Sporting | | 1:0 (0:0) |
| Porto Alegre |
Copa Libertadores 2018, Group 1 |
| 15.05.2018 | | Defensor Sporting | – | Cerro Porteño |  | 0:1 (0:0) |
| Montevideo |
Copa Libertadores 2018, Group 1 |
| 25.04.2018 | | Monagas | – | Defensor Sporting | | 1:0 (0:0) |
| Maturín |
Copa Libertadores 2018, Group 1 |
| 13.03.2018 | | Cerro Porteño | – | Defensor Sporting | | 2:1 (1:0) |
| Asunción |
Copa Libertadores 2014, Semifinal |
| 22.07.2014 | | Nacional Asunción | – | Defensor Sporting | | 2:0 (1:0) |
| Asunción |
Copa Libertadores 2014, Round of 16 |
| 17.04.2014 | | The Strongest | – | Defensor Sporting | | 2:0 (0:0) |
| La Paz |
Copa Libertadores 2014, Group 5 |
| 13.02.2014 |  | Universidad de Chile | – | Defensor Sporting | | 1:0 (0:0) |
| Santiago |
Copa Libertadores 2013, Preliminary Round |
| 31.01.2013 | | Olimpia | – | Defensor Sporting | | 2:0 (1:0) |
| Asunción |
Copa Libertadores 2012, Group 7 |
| 10.04.2012 | | Deportivo Quito | – | Defensor Sporting | | 2:0 (1:0) |
| Quito |
Copa Libertadores 2012, Group 7 |
| 13.03.2012 |  | Guadalajara | – | Defensor Sporting | | 1:0 (1:0) |
| Guadalajara |
Copa Libertadores 2012, Group 7 |
| 07.02.2012 | | Defensor Sporting | – | Vélez Sársfield |  | 0:3 (0:1) |
| Montevideo |
Copa Libertadores 2009, Quarterfinal |
| 18.06.2009 | | Estudiantes La Plata | – | Defensor Sporting | | 1:0 (1:0) |
| La Plata |
Copa Libertadores 2009, Quarterfinal |
| 28.05.2009 | | Defensor Sporting | – | Estudiantes La Plata | | 0:1 (0:1) |
| Montevideo |
Copa Libertadores 2009, Group 4 |
| 09.04.2009 | | São Paulo | – | Defensor Sporting | | 2:1 (0:1) |
| São Paulo |
Copa Libertadores 2009, Group 4 |
| 18.03.2009 | | Defensor Sporting | – | São Paulo | | 0:1 (0:1) |
| Montevideo |
Copa Libertadores 2007, Quarterfinal |
| 23.05.2007 | | Grêmio | – | Defensor Sporting | | 2:0 (2:0),
pen. 4:2 |
| Porto Alegre |
Copa Libertadores 2007, 1/8 finals |
| 09.05.2007 | | Flamengo | – | Defensor Sporting | | 2:0 (1:0) |
| Rio de Janeiro |
Copa Libertadores 2007, Group 8 |
| 19.04.2007 | | Gimnasia y Esgrima | – | Defensor Sporting | | 3:0 (2:0) |
| La Plata |
Copa Libertadores 2007, Group 8 |
| 05.04.2007 | | Defensor Sporting | – | Santos | | 0:2 (0:0) |
| Montevideo |
Copa Libertadores 2007, Group 8 |
| 01.03.2007 | | Santos | – | Defensor Sporting | | 1:0 (0:0) |
| Santos |
Copa Libertadores 2001, Group 7 |
| 04.05.2001 | | Defensor Sporting | – | São Caetano | | 0:1 (0:1) |
| Montevideo |
Copa Libertadores 2001, Group 7 |
| 07.03.2001 | | Olmedo | – | Defensor Sporting | | 4:2 (2:1) |
| Riobamba |
Copa Libertadores 2001, Group 7 |
| 20.02.2001 | | Cruz Azul | – | Defensor Sporting | | 2:0 (1:0) |
| Ciudad de México |
Copa Libertadores 1996, 1/8 finals |
| 30.04.1996 | | Universidad de Chile | – | Defensor Sporting | | 3:2 (3:1) |
| Santiago |
Copa Libertadores 1996, Group 2 |
| 18.03.1996 | | Defensor Sporting | – | Peñarol | | 2:4 (2:2) |
| Montevideo |
Copa Libertadores 1994, Group 4 |
| 13.03.1994 | | Colo-Colo | – | Defensor Sporting | | 2:0 (1:0) |
| Santiago |
Copa Libertadores 1994, Group 4 |
| 08.03.1994 | | Unión Española | – | Defensor Sporting | | 1:0 (1:0) |
| Santiago |
Copa Libertadores 1992, 1/8 finals |
| 06.05.1992 | | Newell's Old Boys | – | Defensor Sporting | | 1:0 (0:0) |
| Rosario |
Copa Libertadores 1992, Group 5 |
| 21.03.1992 | | Defensor Sporting | – | Sol de América | | 1:2 (1:1) |
| Montevideo |
Copa Libertadores 1992, Group 5 |
| 10.03.1992 | | Defensor Sporting | – | Cerro Porteño | | 2:3 (1:1) |
| Montevideo |
Copa Libertadores 1992, Group 5 |
| 04.03.1992 | | Defensor Sporting | – | Nacional Montevideo | | 0:1 (0:1) |
| Montevideo |
Copa Libertadores 1990, 1/8 finals |
| 12.08.1990 | | River Plate | – | Defensor Sporting | | 2:1 (0:1) |
| Buenos Aires |
Copa Libertadores 1990, 1/8 finals |
| 05.08.1990 | | Defensor Sporting | – | River Plate | | 1:2 (1:0) |
| Montevideo |
Copa Libertadores 1990, Group 4 |
| 04.04.1990 | | Progreso | – | Defensor Sporting | | 4:0 (0:0) * |
| Montevideo |
Copa Libertadores 1990, Group 4 |
| 11.03.1990 | | Pepeganga Margarita | – | Defensor Sporting | | 1:0 (1:0) |
| San Cristóbal |
Copa Libertadores 1982, First Round, Group 2 |
| 21.09.1982 | | São Paulo | – | Defensor Sporting | | 2:1 (1:0) |
| São Paulo |
Copa Libertadores 1982, First Round, Group 2 |
| 17.08.1982 | | Defensor Sporting | – | São Paulo | | 1:3 (0:1) |
| Montevideo |
Copa Libertadores 1982, First Round, Group 2 |
| 05.08.1982 | | Peñarol | – | Defensor Sporting | | 3:0 (1:0) |
| Montevideo |
Copa Libertadores 1980, First Round, Group 2 |
| 23.04.1980 | | Defensor Sporting | – | Nacional Montevideo | | 0:3 (0:1) |
| Montevideo |
Copa Libertadores 1980, First Round, Group 2 |
| 13.04.1980 | | The Strongest | – | Defensor Sporting | | 2:0 (1:0) |
| La Paz |
Copa Libertadores 1980, First Round, Group 2 |
| 09.04.1980 | | Nacional Montevideo | – | Defensor Sporting | | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 1977, First Round, Group 1 |
| 18.05.1977 | | Defensor Sporting | – | Peñarol | | 2:4 (2:3) |
| Montevideo |
Copa Libertadores 1977, First Round, Group 1 |
| 28.04.1977 | | Boca Juniors | – | Defensor Sporting | | 2:0 (1:0) |
| Buenos Aires |
