Copa Libertadores 2021, Group D |
 | 19.05.2021 | | River Plate | – | Santa Fe | | 2:1 (2:0) * |
| Buenos Aires |
Copa Libertadores 2021, Group D |
| 12.05.2021 | | Fluminense | – | Santa Fe | | 2:1 (0:0) * |
| Rio de Janeiro |
Copa Libertadores 2021, Group D |
| 28.04.2021 | | Santa Fe | – | Fluminense | | 1:2 (0:1) * |
| Armenia |
Copa Libertadores 2018, Group 4 |
| 03.05.2018 | | Santa Fe | – | River Plate | | 0:1 (0:1) |
| Bogotá |
Copa Libertadores 2017, Group 2 |
| 04.05.2017 | | Santos | – | Santa Fe | | 3:2 (2:2) |
| Santos |
Copa Libertadores 2017, Group 2 |
| 09.03.2017 | | The Strongest | – | Santa Fe | | 2:0 (0:0) |
| La Paz |
Copa Libertadores 2016, Group 8 |
| 20.04.2016 | | Cerro Porteño | – | Santa Fe | | 1:0 (1:0) |
| Asunción |
Copa Libertadores 2016, Group 8 |
| 02.03.2016 | | Corinthians | – | Santa Fe | | 1:0 (0:0) |
| São Paulo |
Copa Libertadores 2015, Quarterfinal |
| 27.05.2015 | | Internacional | – | Santa Fe | | 2:0 (1:0) |
| Porto Alegre |
Copa Libertadores 2015, Round of 16 |
| 05.05.2015 | | Estudiantes | – | Santa Fe | | 2:1 (2:0) |
| La Plata |
Copa Libertadores 2015, Group 1 |
| 09.04.2015 | | Atlético Mineiro | – | Santa Fe | | 2:0 (1:0) |
| Belo Horizonte |
Copa Libertadores 2015, Group 1 |
| 18.03.2015 | | Santa Fe | – | Atlético Mineiro | | 0:1 (0:0) |
| Bogotá |
Copa Libertadores 2014, Group 4 |
| 10.04.2014 | | Nacional Asunción | – | Santa Fe | | 3:2 (1:1) |
| Asunción |
Copa Libertadores 2014, Group 4 |
| 12.03.2014 | | Zamora | – | Santa Fe | | 2:1 (0:0) |
| Barinas |
Copa Libertadores 2014, Group 4 |
| 26.02.2014 | | Atlético-MG | – | Santa Fe | | 2:1 (0:0) |
| Belo Horizonte |
Copa Libertadores 2014, Preliminary Round |
| 28.01.2014 | | Monarcas | – | Santa Fe | | 2:1 (1:0) |
| Morelia |
Copa Libertadores 2013, Semifinal |
| 02.07.2013 | | Olimpia | – | Santa Fe | | 2:0 (0:0) |
| Asunción |
Copa Libertadores 2013, Round of 16 |
| 01.05.2013 | | Grêmio | – | Santa Fe | | 2:1 (1:0) |
| Porto Alegre |
Copa Libertadores 2006, 1/8 finals |
| 26.04.2006 | | Guadalajara | – | Santa Fe | | 3:0 (1:0) |
| Guadalajara |
Copa Libertadores 2006, Group 2 |
| 28.03.2006 | | Bolívar | – | Santa Fe | | 1:0 (0:0) |
| La Paz |
Copa Libertadores 2006, Group 2 |
| 21.03.2006 | | Estudiantes La Plata | – | Santa Fe | | 1:0 (0:0) |
| Quilmes |
Copa Libertadores 1980, First Round, Group 4 |
| 30.03.1980 | | Santa Fe | – | Emelec | | 1:2 (0:2) |
| Bogotá |
Copa Libertadores 1980, First Round, Group 4 |
| 26.03.1980 | | Universidad Católica | – | Santa Fe | | 1:0 (1:0) |
| Quito |
Copa Libertadores 1980, First Round, Group 4 |
| 12.03.1980 | | América de Cali | – | Santa Fe | | 1:0 (1:0) |
| Santiago de Cali |
Copa Libertadores 1976, First Round, Group 4 |
| 07.04.1976 | | Alfonso Ugarte | – | Santa Fe | | 2:1 (0:1) |
| Puno |
Copa Libertadores 1976, First Round, Group 4 |
| 04.04.1976 | | Alianza Lima | – | Santa Fe | | 3:0 (2:0) |
| Lima |
Copa Libertadores 1976, First Round, Group 4 |
| 11.03.1976 | | Santa Fe | – | Alianza Lima | | 2:3 (1:2) |
| Bogotá |
Copa Libertadores 1972, First Round, Group 1 |
| 23.03.1972 | | Rosario Central | – | Santa Fe | | 2:0 (1:0) |
| Rosario |
Copa Libertadores 1972, First Round, Group 1 |
| 21.03.1972 | | Independiente Avellaneda | – | Santa Fe | | 2:0 (2:0) |
| Avellaneda |
Copa Libertadores 1972, First Round, Group 1 |
| 24.02.1972 | | Santa Fe | – | Independiente Avellaneda | | 2:4 (1:2) |
| Bogotá |
Copa Libertadores 1967, First Round, Group 2 |
| 10.05.1967 | | Santa Fe | – | Bolívar | | 1:2 (0:1) |
| Bogotá |
Copa Libertadores 1967, First Round, Group 2 |
| 24.04.1967 | | 31 de Octubre | – | Santa Fe | | 6:2 (4:0) |
| La Paz |
Copa Libertadores 1967, First Round, Group 2 |
| 20.04.1967 | | Racing Club | – | Santa Fe | | 4:1 (2:0) |
| Avellaneda |
Copa Libertadores 1967, First Round, Group 2 |
| 18.04.1967 | | River Plate | – | Santa Fe | | 4:0 (2:0) |
| Buenos Aires |
Copa Libertadores 1967, First Round, Group 2 |
| 29.03.1967 | | Santa Fe | – | Racing Club | | 1:2 (0:1) |
| Bogotá |
Copa Libertadores 1961, Semifinal |
| 28.05.1961 | | Palmeiras | – | Santa Fe | | 4:1 (3:0) |
| São Paulo |
Copa Libertadores 1961, Quarterfinal |
| 30.04.1961 | | Jorge Wilstermann | – | Santa Fe | | 3:2 (2:1) |
| Cochabamba |
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