Copa Sudamericana 2022, Round of 16 |
 | 06.07.2022 |  | Melgar | – | Deportivo Cali |  | 2:1 (0:0) |
| Arequipa |
Copa Sudamericana 2022, Round of 16 |
| 29.06.2022 | | Deportivo Cali | – | Melgar | | 0:0 |
| Santiago de Cali |
Copa Sudamericana 2021, First stage |
| 06.04.2021 | | Deportivo Cali | – | Deportes Tolima | | 0:0 * |
| Santiago de Cali |
Copa Sudamericana 2021, First stage |
| 16.03.2021 | | Deportes Tolima | – | Deportivo Cali | | 3:0 (2:0) * |
| Ibagué |
Copa Sudamericana 2020, Round of 16 |
| 01.12.2020 | | Deportivo Cali | – | Vélez Sársfield |  | 1:5 (1:2) * |
| Santiago de Cali |
Copa Sudamericana 2020, Round of 16 |
| 24.11.2020 | | Vélez Sársfield | – | Deportivo Cali | | 2:0 (0:0) * |
| Buenos Aires |
Copa Sudamericana 2020, Second round |
| 04.11.2020 | | Deportivo Cali | – | Los Millonarios | | 1:2 (1:1),
pen. 5:4 |
| Santiago de Cali |
Copa Sudamericana 2020, Second round |
| 28.10.2020 | | Los Millonarios | – | Deportivo Cali | | 1:2 (0:0) |
| Bogotá |
Copa Sudamericana 2020, First stage |
| 25.02.2020 |  | River Plate Asunción | – | Deportivo Cali | | 1:3 (0:1) |
| Asunción |
Copa Sudamericana 2020, First stage |
| 11.02.2020 | | Deportivo Cali | – | River Plate Asunción | | 2:1 (2:0) |
| Santiago de Cali |
Copa Sudamericana 2019, Second round |
| 29.05.2019 |  | Peñarol | – | Deportivo Cali | | 2:0 (0:0) |
| Montevideo |
Copa Sudamericana 2019, Second round |
| 22.05.2019 | | Deportivo Cali | – | Peñarol | | 1:1 (0:0) |
| Santiago de Cali |
Copa Sudamericana 2019, First stage |
| 02.05.2019 | | Guaraní | – | Deportivo Cali | | 1:0 (0:0),
pen. 1:4 |
| Asunción |
Copa Sudamericana 2019, First stage |
| 04.04.2019 | | Deportivo Cali | – | Guaraní | | 1:0 (1:0) |
| Santiago de Cali |
Copa Sudamericana 2018, Quarterfinal |
| 30.10.2018 | | Deportivo Cali | – | Santa Fe | | 1:2 (0:2) |
| Santiago de Cali |
Copa Sudamericana 2018, Quarterfinal |
| 23.10.2018 | | Santa Fe | – | Deportivo Cali | | 1:1 (1:1) |
| Bogotá |
Copa Sudamericana 2018, Round of 16 |
| 19.09.2018 | | Deportivo Cali | – | LDU |  | 1:0 (1:0),
pen. 3:1 |
| Santiago de Cali |
Copa Sudamericana 2018, Round of 16 |
| 22.08.2018 | | LDU | – | Deportivo Cali | | 1:0 (1:0) |
| Quito |
Copa Sudamericana 2018, Second round |
| 02.08.2018 |  | Bolívar | – | Deportivo Cali | | 1:2 (0:0) |
| La Paz |
Copa Sudamericana 2018, Second round |
| 18.07.2018 | | Deportivo Cali | – | Bolívar | | 4:0 (1:0) |
| Santiago de Cali |
Copa Sudamericana 2018, First stage |
| 08.05.2018 | | Danubio | – | Deportivo Cali | | 3:2 (1:0) |
| Montevideo |
Copa Sudamericana 2018, First stage |
| 10.04.2018 | | Deportivo Cali | – | Danubio | | 3:0 (1:0) |
| Santiago de Cali |
Copa Sudamericana 2017, Second round |
| 03.08.2017 | | Junior | – | Deportivo Cali | | 1:1 (0:1),
pen. 3:2 |
| Barranquilla |
Copa Sudamericana 2017, Second round |
| 13.07.2017 | | Deportivo Cali | – | Junior | | 1:1 (1:0) |
| Santiago de Cali |
Copa Sudamericana 2017, First Round |
| 09.05.2017 | | Luqueño | – | Deportivo Cali | | 2:1 (2:1) |
| Luque |
Copa Sudamericana 2017, First Round |
| 28.02.2017 | | Deportivo Cali | – | Luqueño | | 1:0 (0:0) |
| Santiago de Cali |
Copa Sudamericana 2014, Second round |
| 24.09.2014 | | Deportivo Cali | – | Peñarol | | 0:1 (0:1) |
| Santiago de Cali |
Copa Sudamericana 2014, Second round |
| 16.09.2014 | | Peñarol | – | Deportivo Cali | | 2:2 (0:0) |
| Montevideo |
Copa Sudamericana 2014, First Round |
| 28.08.2014 | | Deportivo Cali | – | Universidad Técnica | | 3:0 (2:0) |
| Santiago de Cali |
Copa Sudamericana 2014, First Round |
| 20.08.2014 | | Universidad Técnica | – | Deportivo Cali | | 0:0 |
| Cajamarca |
Copa Sudamericana 2011, First Round |
| 22.09.2011 | | Deportivo Cali | – | Santa Fe | | 1:1 (1:0),
pen. 5:6 |
| Santiago de Cali |
Copa Sudamericana 2011, First Round |
| 15.09.2011 | | Santa Fe | – | Deportivo Cali | | 1:1 (0:0) |
| Bogotá |
Copa Sudamericana 2009, First Round |
| 18.08.2009 | | Deportivo Cali | – | Universidad de Chile |  | 0:1 (0:0) |
| Santiago de Cali |
Copa Sudamericana 2009, First Round |
| 04.08.2009 | | Universidad de Chile | – | Deportivo Cali | | 2:1 (0:0) |
| Santiago |
Copa Sudamericana 2008, First Round |
| 16.09.2008 | | Deportivo Cali | – | América | | 1:0 (0:0) |
| Santiago de Cali |
Copa Sudamericana 2008, First Round |
| 14.08.2008 | | América | – | Deportivo Cali | | 2:0 (0:0) |
| Santiago de Cali |
Copa Sudamericana 2005, Section 6, First Stage |
| 23.08.2005 | | Atlético Nacional | – | Deportivo Cali | | 2:0 (2:0),
pen. 7:6 |
| Medellín |
Copa Sudamericana 2005, Section 6, First Stage |
| 16.08.2005 | | Deportivo Cali | – | Atlético Nacional | | 2:0 (1:0) |
| Santiago de Cali |
