Europa League 2022/23, Semifinal |
 | 11.05.2023 |  | Roma | – | Bayer 04 |  | 1:0 (0:0) |
| Roma |
Europa League 2022/23, Round of 32 |
| 16.02.2023 | | Bayer 04 | – | Monaco |  | 2:3 (0:1) |
| Leverkusen |
Europa League 2021/22, Round of 16 |
| 17.03.2022 | | Bayer 04 | – | Atalanta | | 0:1 (0:0) |
| Leverkusen |
Europa League 2021/22, Round of 16 |
| 10.03.2022 | | Atalanta | – | Bayer 04 | | 3:2 (2:1) |
| Bergamo |
Europa League 2021/22, Group G |
| 09.12.2021 |  | Ferencváros | – | Bayer 04 | | 1:0 (0:0) |
| Budapest |
Europa League 2020/21, Round of 32 |
| 25.02.2021 | | Bayer 04 | – | Young Boys |  | 0:2 (0:0) * |
| Leverkusen |
Europa League 2020/21, Round of 32 |
| 18.02.2021 | | Young Boys | – | Bayer 04 | | 4:3 (3:0) * |
| Bern |
Europa League 2020/21, Group C |
| 29.10.2020 |  | Slavia Prague | – | Bayer 04 | | 1:0 (0:0) * |
| Praha |
Europa League 2019/20, Quarterfinal |
| 10.08.2020 | | Inter | – | Bayer 04 | | 2:1 (2:1) * |
| Germany, Düsseldorf |
Europa League 2018/19, Group A |
| 25.10.2018 | | Zürich | – | Bayer 04 | | 3:2 (1:0) |
| Zürich |
Europa League 2015/16, Round of 16 |
| 10.03.2016 |  | Villarreal | – | Bayer 04 | | 2:0 (1:0) |
| Villarreal |
Europa League 2012/13, Round of 32 |
| 21.02.2013 |  | Benfica | – | Bayer 04 | | 2:1 (0:0) |
| Lisboa |
Europa League 2012/13, Round of 32 |
| 14.02.2013 | | Bayer 04 | – | Benfica | | 0:1 (0:0) |
| Leverkusen |
Europa League 2012/13, Group K |
| 22.11.2012 |  | Metalist Kharkiv | – | Bayer 04 | | 2:0 (0:0) |
 | Kharkiv |
Europa League 2010/11, Round of 16 |
| 17.03.2011 | | Villarreal | – | Bayer 04 | | 2:1 (1:0) |
| Villarreal |
Europa League 2010/11, Round of 16 |
| 10.03.2011 | | Bayer 04 | – | Villarreal | | 2:3 (1:1) |
| Leverkusen |
UEFA Cup 2007/08, Quarterfinal |
| 03.04.2008 | | Bayer 04 | – | Zenit |  | 1:4 (1:1) |
| Leverkusen |
UEFA Cup 2007/08, 1/8 finals |
| 12.03.2008 | | Hamburger SV | – | Bayer 04 | | 3:2 (0:1) |
| Hamburg |
UEFA Cup 2007/08, Group E |
| 08.11.2007 | | Spartak Moscow | – | Bayer 04 | | 2:1 (0:0) |
| Moscow |
UEFA Cup 2007/08, First Round |
| 05.10.2007 | | União de Leiria | – | Bayer 04 | | 3:2 (2:1) |
| Leiria |
UEFA Cup 2006/07, Quarterfinal |
| 12.04.2007 | | Atlético Osasuna | – | Bayer 04 | | 1:0 (0:0) |
| Pamplona |
UEFA Cup 2006/07, Quarterfinal |
| 05.04.2007 | | Bayer 04 | – | Atlético Osasuna | | 0:3 (0:1) |
| Leverkusen |
UEFA Cup 2006/07, 1/8 finals |
| 08.03.2007 | | Lens | – | Bayer 04 | | 2:1 (1:0) |
| Lens |
UEFA Cup 2006/07, Group B |
| 29.11.2006 |  | Dinamo Bucureşti | – | Bayer 04 | | 2:1 (1:1) |
| Bucureşti |
UEFA Cup 2006/07, Group B |
| 23.11.2006 | | Bayer 04 | – | Tottenham Hotspur |  | 0:1 (0:1) |
| Leverkusen |
UEFA Cup 2005/06, First Round |
| 29.09.2005 |  | CSKA Sofia | – | Bayer 04 | | 1:0 (0:0) |
| Sofia |
UEFA Cup 2005/06, First Round |
| 15.09.2005 | | Bayer 04 | – | CSKA Sofia | | 0:1 (0:1) |
| Leverkusen |
UEFA Cup 2000/01, 1/16 finals |
| 07.12.2000 |  | AÉK | – | Bayer 04 | | 2:0 (1:0) |
| Athens |
UEFA Cup 1999/00, 1/16 finals |
| 09.12.1999 | | Bayer 04 | – | Udinese | | 1:2 (1:2) |
| Leverkusen |
UEFA Cup 1998/99, 1/16 finals |
| 22.10.1998 | | Bayer 04 | – | Rangers |  | 1:2 (0:1) |
| Leverkusen |
UEFA Cup 1994/95, Semifinal |
| 18.04.1995 | | Parma | – | Bayer 04 | | 3:0 (1:0) |
| Parma |
UEFA Cup 1994/95, Semifinal |
| 04.04.1995 | | Bayer 04 | – | Parma | | 1:2 (1:0) |
| Leverkusen |
