Copa Libertadores 2021, Third round |
 | 13.04.2021 |  | Santos | – | San Lorenzo de Almagro |  | 2:2 (1:0) |
| Brasília |
Copa Libertadores 2021, Second round |
| 16.03.2021 |  | Deportivo Lara | – | Santos | | 1:1 (0:1) |
| Caracas |
Copa Libertadores 2020, Semifinal |
| 06.01.2021 | | Boca Juniors | – | Santos | | 0:0 * |
| Buenos Aires |
Copa Libertadores 2020, Quarterfinal |
| 09.12.2020 | | Grêmio | – | Santos | | 1:1 (0:1) * |
| Porto Alegre |
Copa Libertadores 2020, Group G |
| 15.09.2020 | | Santos | – | Olimpia |  | 0:0 |
| Santos |
Copa Libertadores 2018, Round of 16 |
| 28.08.2018 | | Santos | – | Independiente | | 0:0 |
| São Paulo |
Copa Libertadores 2018, Group 6 |
| 24.05.2018 | | Santos | – | Real Garcilaso |  | 0:0 |
| Santos |
Copa Libertadores 2017, Quarterfinal |
| 13.09.2017 |  | Barcelona | – | Santos | | 1:1 (0:0) |
| Guayaquil |
Copa Libertadores 2017, Group 2 |
| 17.05.2017 |  | The Strongest | – | Santos | | 1:1 (1:0) |
| La Paz |
Copa Libertadores 2017, Group 2 |
| 19.04.2017 |  | Santa Fe | – | Santos | | 0:0 |
| Bogotá |
Copa Libertadores 2017, Group 2 |
| 09.03.2017 | | Sporting Cristal | – | Santos | | 1:1 (1:0) |
| Lima |
Copa Libertadores 2012, Semifinal |
| 20.06.2012 | | Corinthians | – | Santos | | 1:1 (0:1) |
| São Paulo |
Copa Libertadores 2012, Group 1 |
| 04.04.2012 | | Internacional | – | Santos | | 1:1 (1:0) |
| Porto Alegre |
Copa Libertadores 2011, Final |
| 15.06.2011 |  | Peñarol | – | Santos | | 0:0 |
| Montevideo |
Copa Libertadores 2011, Semifinal |
| 01.06.2011 | | Cerro Porteño | – | Santos | | 3:3 (1:3) |
| Asunción |
Copa Libertadores 2011, Quarterfinals |
| 18.05.2011 | | Santos | – | Once Caldas | | 1:1 (1:1) |
| São Paulo |
Copa Libertadores 2011, 1/8 finals |
| 03.05.2011 |  | América | – | Santos | | 0:0 |
| Ciudad de México |
Copa Libertadores 2011, Group 5 |
| 02.03.2011 | | Santos | – | Cerro Porteño | | 1:1 (0:0) |
| Santos |
Copa Libertadores 2011, Group 5 |
| 15.02.2011 | | Deportivo Táchira | – | Santos | | 0:0 |
| San Cristóbal |
Copa Libertadores 2008, Group 6 |
| 13.02.2008 | | Cúcuta Deportivo | – | Santos | | 0:0 |
| Cúcuta |
Copa Libertadores 2007, Quarterfinal |
| 16.05.2007 | | América Mexico | – | Santos | | 0:0 |
| Ciudad de México |
Copa Libertadores 2007, 1/8 finals |
| 02.05.2007 | | Caracas | – | Santos | | 2:2 (0:1) |
| Caracas |
Copa Libertadores 2004, Quarterfinal |
| 19.05.2004 | | Santos | – | Once Caldas | | 1:1 (0:0) |
| Santos |
Copa Libertadores 2004, Group 7 |
| 18.02.2004 | | Santos | – | Guaraní Asunción | | 2:2 (1:0) |
| Santos |
Copa Libertadores 2003, Quarterfinal |
| 21.05.2003 | | Cruz Azul | – | Santos | | 2:2 (1:1) |
| Ciudad de México |
Copa Libertadores 2003, 1/8 finals |
| 07.05.2003 | | Santos | – | Nacional Montevideo | | 2:2 (1:2),
pen. 3:1 |
| Santos |
Copa Libertadores 2003, 1/8 finals |
| 23.04.2003 | | Nacional Montevideo | – | Santos | | 4:4 (0:2) |
| Montevideo |
Copa Libertadores 2003, Group 3 |
| 16.04.2003 | | Santos | – | El Nacional | | 1:1 (1:0) |
| Santos |
Copa Libertadores 2003, Group 3 |
| 12.03.2003 | | El Nacional | – | Santos | | 0:0 |
| Quito |
Copa Libertadores 1963, Semifinal |
| 22.08.1963 | | Santos | – | Botafogo | | 1:1 (0:0) |
| São Paulo |
Copa Libertadores 1962, Semifinal |
| 08.07.1962 |  | Universidad Católica | – | Santos | | 1:1 (0:0) |
| Santiago |
Copa Libertadores 1962, Group A |
| 25.02.1962 | | Cerro Porteño | – | Santos | | 1:1 (0:0) |
| Asunción |
