CONCACAF Champions League 2022, Final tournament, Round of 16 |
 | 23.02.2022 |  | Montréal | – | Santos Laguna |  | 3:0 (2:0) |
| Montréal |
CONCACAF Champions League 2019, Final tournament, Semifinal |
| 03.04.2019 | | Tigres UANL | – | Santos Laguna | | 3:0 (3:0) |
| San Nicolás de los Garza |
CONCACAF Champions League 2015/16, Final tournament, Semifinal |
| 05.04.2016 | | América | – | Santos Laguna | | 1:0 aet
(0:0) |
| Ciudad de México |
CONCACAF Champions League 2015/16, Final tournament, Group A |
| 25.08.2015 |  | Saprissa | – | Santos Laguna | | 2:1 (0:1) |
| San José |
CONCACAF Champions League 2012/13, Final tournament, Final |
| 01.05.2013 | | Monterrey | – | Santos Laguna | | 4:2 (0:1) |
| Monterrey |
CONCACAF Champions League 2012/13, Final tournament, Quarterfinal |
| 05.03.2013 |  | Houston Dynamo | – | Santos Laguna | | 1:0 (0:0) |
| Houston |
CONCACAF Champions League 2011/12, Final tournament, Final |
| 18.04.2012 | | Monterrey | – | Santos Laguna | | 2:0 (0:0) |
| Monterrey |
CONCACAF Champions League 2011/12, Final tournament, Quarterfinal |
| 07.03.2012 | | Seattle Sounders | – | Santos Laguna | | 2:1 (1:0) |
| Seattle |
CONCACAF Champions League 2011/12, Final tournament, Group B |
| 24.08.2011 |  | Isidro Metapan | – | Santos Laguna | | 2:0 (1:0) |
| Metapán |
CONCACAF Champions League 2011/12, Final tournament, Preliminary Round |
| 03.08.2011 |  | Olimpia | – | Santos Laguna | | 2:1 (1:1) |
| Tegucigalpa |
CONCACAF Champions League 2010/11, Final tournament, Quarterfinal |
| 01.03.2011 | | Santos Laguna | – | Cruz Azul | | 1:3 (0:1) |
| Torreón |
CONCACAF Champions League 2010/11, Final tournament, Quarterfinal |
| 22.02.2011 | | Cruz Azul | – | Santos Laguna | | 2:0 (0:0) |
| Ciudad de México |
CONCACAF Champions League 2010/11, Final tournament, Group B |
| 21.09.2010 | | Columbus Crew | – | Santos Laguna | | 1:0 (0:0) |
| Columbus |
CONCACAF Champions League 2008/09, Final tournament, Semifinal |
| 08.04.2009 | | Atlante | – | Santos Laguna | | 3:1 (1:0) |
| Cancún |
CONCACAF Champions League 2008/09, Final tournament, Quarterfinal |
| 25.02.2009 | | Montreal Impact | – | Santos Laguna | | 2:0 (1:0) |
| Montreal |
CONCACAF Champions League 2008/09, Final tournament, Group D |
| 02.10.2008 |  | Tauro | – | Santos Laguna | | 2:0 (1:0) |
| Ciudad de Panamá |
CONCACAF Champions League 2008/09, Final tournament, Group D |
| 23.09.2008 |  | Puerto Rico Islanders | – | Santos Laguna | | 3:1 (2:0) |
| Bayamón |
CONCACAF Champions Cup 2001/02, Final tournament, Quarterfinal |
| 24.04.2002 | | Kansas City Wizards | – | Santos Laguna | | 2:0 (1:0) |
| Kansas City |
Copa de Campeones y Subcampeones CONCACAF 1997, Qualifying, Northern Zone, Qualifying round |
| 30.07.1997 | | Los Angeles Galaxy | – | Santos Laguna | | 4:1 (0:0) |
| Los Angeles |
Copa de Campeones y Subcampeones CONCACAF 1995, Qualifying, Northern/Central Zone, Group 2, Round 2 |
| 22.07.1995 | | FAS | – | Santos Laguna | | 3:0 (2:0) |
| Santa Ana |
