FA Cup 2023/24, Second Qualifying Round |
 | 19.09.2023 |  | AFC Emley | – | Mossley AFC | | 3:1 aet
(0:0, 1:1) * |
| Emley |
FA Cup 2022/23, Preliminary Round |
| 20.08.2022 | | Mossley AFC | – | Macclesfield Town | | 2:4 (1:1) |
| Mossley |
FA Cup 2021/22, Second qualifying round |
| 18.09.2021 | | Mossley AFC | – | Radcliffe | | 1:2 (1:0) |
| Mossley |
FA Cup 2019/20, Preliminary Round |
| 03.09.2019 | | Mossley AFC | – | Widnes | | 2:3 (0:1) * |
| Mossley |
FA Cup 2018/19, Second Qualifying Round |
| 22.09.2018 | | Mossley AFC | – | Kidsgrove Athletic | | 1:2 (0:0) |
| Mossley |
FA Cup 2017/18, First Qualifying Round |
| 05.09.2017 | | 1874 Northwich | – | Mossley AFC | | 2:0 (2:0) * |
| Winsford |
FA Cup 2016/17, First Qualifying Round |
| 03.09.2016 | | Ashton Athletic | – | Mossley AFC | | 7:2 |
| Ashton-in-Makerfield |
FA Cup 2015/16, Preliminary Round |
| 01.09.2015 | | Bamber Bridge | – | Mossley AFC | | 3:1 (1:1) * |
| Bamber Bridge |
FA Cup 2013/14, Preliminary Round |
| 03.09.2013 | | Worksop Parramore | – | Mossley | | 3:2 * |
| Worksop |
FA Cup 2012/13, Preliminary Round |
| 25.08.2012 | | Mossley | – | Bootle | | 0:3 |
| Mossley |
FA Cup 2011/12, Preliminary Round |
| 06.09.2011 | | Runcorn Linnets | – | Mossley | | 4:0 * |
| |
FA Cup 2010/11, Fourth Qualifying Round |
| 23.10.2010 | | Mossley | – | Darlington | | 2:6 |
| Mossley |
FA Cup 2009/10, Preliminary Round |
| 29.08.2009 | | Cammell Laird | – | Mossley | | 2:1 |
| |
FA Cup 2008/09, Third Qualifying Round |
| 11.10.2008 | | Curzon Ashton | – | Mossley | | 4:3 (3:1) |
| |
FA Cup 2007/08, Preliminary Round |
| 04.09.2007 | | Mossley | – | Woodley Sports | | 1:2 * |
| |
FA Cup 2006/07, First Qualifying Round |
| 16.09.2006 | | Guiseley | – | Mossley | | 2:1 |
| |
FA Cup 2005/06, First Qualifying Round |
| 10.09.2005 | | Armthorpe Welfare | – | Mossley | | 3:1 |
| |
FA Cup 2004/05, Third Qualifying Round |
| | | Hinckley United | – | Mossley | | 6:1 (4:0) |
| |
FA Cup 2003/04, First Qualifying Round |
| | | Mossley | – | Hyde United | | 1:6 |
| |
FA Cup 2002/03, First Qualifying Round |
| | | Workington | – | Mossley | | 2:1 |
| |
FA Cup 2001/02, Preliminary Round |
| | | Spennymoor United | – | Mossley | | 4:2 |
| |
FA Cup 2000/01, Third Qualifying Round |
| | | Frickley Athletic | – | Mossley | | 3:0 * |
| |
FA Cup 1999/00, First Qualifying Round |
| | | Mossley | – | Gretna |  | 0:2 |
| |
FA Cup 1998/99, Third Qualifying Round |
| | | Mossley | – | Lancaster City | | 0:1 |
| |
FA Cup 1997/98, First Qualifying Round |
| | | Gretna | – | Mossley | | 3:0 |
| |
FA Cup 1996/97, Second Qualifying Round |
| | | Farsley Celtic | – | Mossley | | 3:1 |
| |
FA Cup 1995/96, Third Qualifying Round |
| | | Guiseley | – | Mossley | | 6:1 |
| |
FA Cup 1994/95, First Qualifying Round |
| | | Mossley | – | Northwich Victoria | | 2:4 |
| |
FA Cup 1993/94, Preliminary Round |
| | | Lincoln United | – | Mossley | | 4:2 |
| |
FA Cup 1992/93, Second Qualifying Round |
| | | Mossley | – | Pelsall Villa | | 1:2 |
| |
FA Cup 1991/92, Second Qualifying Round |
| | | Winsford United | – | Mossley | | 6:0 * |
| |
FA Cup 1990/91, First Qualifying Round |
| | | Chorley | – | Mossley | | 4:0 |
| |
FA Cup 1989/90, Fourth Qualifying Round |
| | | Bishop Auckland | – | Mossley | | 3:0 * |
| |
FA Cup 1988/89, Second Qualifying Round |
| | | Leek Town | – | Mossley | | 2:0 |
| |
FA Cup 1987/88, First Qualifying Round |
| | | Hyde United | – | Mossley | | 1:0 |
| |
FA Cup 1986/87, First Qualifying Round |
| | | Eastwood Town | – | Mossley | | 2:0 * |
| |
FA Cup 1985/86, Third Qualifying Round |
| | | Mossley | – | Runcorn | | 0:2 |
| |
FA Cup 1984/85, Fourth Qualifying Round |
| | | Mossley | – | Goole Town | | 0:1 |
| |
FA Cup 1983/84, First Round Proper |
| 19.11.1983 | | Darlington | – | Mossley | | 5:0 |
| |
FA Cup 1982/83, First Round Proper |
| 20.11.1982 | | Huddersfield Town | – | Mossley | | 1:0 |
| |
FA Cup 1981/82, First Round Proper |
| 21.11.1981 | | Stockport County | – | Mossley | | 3:1 |
| |
FA Cup 1980/81, Second Round Proper |
| 13.12.1980 | | Mossley | – | Mansfield Town | | 1:3 |
| |
FA Cup 1979/80, First Round Proper |
| 24.11.1979 | | York City | – | Mossley | | 5:2 |
| |
FA Cup 1978/79, First Qualifying Round |
| | | Witton Albion | – | Mossley | | 4:2 |
| |
FA Cup 1977/78, First Round Proper |
| 26.11.1977 | | Rotherham United | – | Mossley | | 3:0 |
| |
FA Cup 1976/77, Second Qualifying Round |
| | | Great Harwood | – | Mossley | | 6:0 |
| |
FA Cup 1975/76, First Qualifying Round |
| | | Worksop Town | – | Mossley | | 1:0 |
| |
FA Cup 1974/75, Fourth Qualifying Round |
| | | Mossley | – | Oswestry Town | | 1:3 |
| |
FA Cup 1973/74, Third Qualifying Round |
| | | Buxton | – | Mossley | | 2:1 |
| |
FA Cup 1972/73, First Qualifying Round |
| | | Stalybridge Celtic | – | Mossley | | 4:3 * |
| |
FA Cup 1971/72, Second Qualifying Round |
| | | Hyde United | – | Mossley | | 2:0 * |
| |
FA Cup 1970/71, Preliminary Round |
| | | Mossley | – | Eastwood Hanley | | 0:1 |
| |
FA Cup 1969/70, First Round Proper |
| 18.11.1969 | | Mossley | – | Stockport County | | 0:1 (0:0) * |
| |
FA Cup 1968/69, Fourth Qualifying Round |
| | | Mossley | – | Morecambe | | 1:2 |
| |
FA Cup 1967/68, First Qualifying Round |
| | | Hyde United | – | Mossley | | 3:0 |
| |
FA Cup 1966/67, Second Qualifying Round |
| | | Northwich Victoria | – | Mossley | | 3:1 * |
| |
FA Cup 1965/66, First Qualifying Round |
| | | Mossley | – | Northwich Victoria | | 1:4 |
| |
FA Cup 1964/65, First Qualifying Round |
| | | Northwich Victoria | – | Mossley | | 5:2 |
| |
FA Cup 1963/64, Second Qualifying Round |
| | | Mossley | – | Macclesfield Town | | 0:5 |
| |
FA Cup 1962/63, Second Qualifying Round |
| | | Mossley | – | Droylsden | | 1:2 * |
| |
FA Cup 1961/62, Preliminary Round |
| | | Mossley | – | Congleton Town | | 1:2 |
| |
FA Cup 1960/61, First Qualifying Round |
| | | Mossley | – | Chorley | | 0:1 |
| |
FA Cup 1959/60, Second Qualifying Round |
| | | Altrincham | – | Mossley | | 3:2 |
| |
FA Cup 1958/59, Preliminary Round |
| | | Chorley | – | Mossley | | 1:0 |
| |
FA Cup 1957/58, Second Qualifying Round |
| | | Mossley | – | Chorley | | 1:4 |
| |
FA Cup 1956/57, Third Qualifying Round |
| | | Horwich Railway Mechanics Institute | – | Mossley | | 1:0 |
| |
FA Cup 1955/56, Preliminary Round |
| | | Lytham | – | Mossley | | 1:0 * |
| |
FA Cup 1954/55, Second Qualifying Round |
| | | Darwen | – | Mossley | | 3:1 |
| |
FA Cup 1953/54, Fourth Qualifying Round |
| |  | Rhyl | – | Mossley | | 2:0 * |
| |
FA Cup 1952/53, Third Qualifying Round |
| | | Ashton United | – | Mossley | | 2:1 |
| |
FA Cup 1951/52, Second Qualifying Round |
| | | Darwen | – | Mossley | | 1:0 |
| |
FA Cup 1950/51, Preliminary Round |
| | | Runcorn | – | Mossley | | 3:1 |
| |
FA Cup 1949/50, Second Round Proper |
| 17.12.1949 | | Mossley | – | Nuneaton Borough | | 0:3 * |
| |
FA Cup 1948/49, Extra Preliminary Round |
| | | Ashton United | – | Mossley | | 3:0 |
| |
