Copa Sudamericana 2024, First stage |
 | 06.03.2024 |  | Guaraní | – | Luqueño | | 0:1 (0:0) |
| Asunción |
Copa Sudamericana 2023, Round of 16 |
| 09.08.2023 | | Guaraní | – | Botafogo |  | 0:0 |
| Asunción |
Copa Sudamericana 2023, Round of 16 |
| 02.08.2023 | | Botafogo | – | Guaraní | | 2:1 (0:1) |
| Rio de Janeiro |
Copa Sudamericana 2023, Group B |
| 28.06.2023 | | Guaraní | – | Huracán |  | 2:0 (2:0) |
| Asunción |
Copa Sudamericana 2023, Group B |
| 07.06.2023 |  | Emelec | – | Guaraní | | 1:1 (1:1) |
| Guayaquil |
Copa Sudamericana 2023, Group B |
| 25.05.2023 |  | Danubio | – | Guaraní | | 0:2 (0:0) |
| Montevideo |
Copa Sudamericana 2023, Group B |
| 03.05.2023 | | Guaraní | – | Emelec | | 1:1 (0:0) |
| Asunción |
Copa Sudamericana 2023, Group B |
| 19.04.2023 | | Guaraní | – | Danubio | | 2:1 (0:1) |
| Asunción |
Copa Sudamericana 2023, Group B |
| 06.04.2023 | | Huracán | – | Guaraní | | 4:1 (2:1) |
| Buenos Aires |
Copa Sudamericana 2023, First stage |
| 08.03.2023 | | Guaraní | – | Sportivo Ameliano | | 3:1 (1:0) |
| Asunción |
Copa Sudamericana 2019, First stage |
| 02.05.2019 | | Guaraní | – | Deportivo Cali |  | 1:0 (0:0),
pen. 1:4 |
| Asunción |
Copa Sudamericana 2019, First stage |
| 04.04.2019 | | Deportivo Cali | – | Guaraní | | 1:0 (1:0) |
| Santiago de Cali |
Copa Sudamericana 2013, Second round |
| 27.08.2013 | | Atlético Nacional | – | Guaraní | | 0:0 |
| Medellín |
Copa Sudamericana 2013, Second round |
| 20.08.2013 | | Guaraní | – | Atlético Nacional | | 0:2 (0:1) |
| Asunción |
Copa Sudamericana 2013, First Round |
| 08.08.2013 |  | Oriente Petrolero | – | Guaraní | | 1:4 (0:2) |
| Santa Cruz de la Sierra |
Copa Sudamericana 2013, First Round |
| 01.08.2013 | | Guaraní | – | Oriente Petrolero | | 0:0 |
| Asunción |
Copa Sudamericana 2012, Second round |
| 19.09.2012 | | Millonarios | – | Guaraní | | 1:1 (0:0) |
| Bogotá |
Copa Sudamericana 2012, Second round |
| 30.08.2012 | | Guaraní | – | Millonarios | | 2:4 (0:1) |
| Asunción |
Copa Sudamericana 2012, First Round |
| 09.08.2012 | | Oriente Petrolero | – | Guaraní | | 1:2 (0:1) |
| Santa Cruz de la Sierra |
Copa Sudamericana 2012, First Round |
| 26.07.2012 | | Guaraní | – | Oriente Petrolero | | 0:1 (0:0) |
| Asunción |
Copa Sudamericana 2010, First Round |
| 23.09.2010 |  | Unión | – | Guaraní | | 1:1 (0:1),
pen. 8:7 |
| Santiago |
Copa Sudamericana 2010, First Round |
| 07.09.2010 | | Guaraní | – | Unión | | 1:1 (0:0) |
| Asunción |
Copa Sudamericana 2010, Preliminary Round |
| 01.09.2010 | | River Plate | – | Guaraní | | 4:2 (1:2) |
| Montevideo |
Copa Sudamericana 2010, Preliminary Round |
| 19.08.2010 | | Guaraní | – | River Plate | | 2:0 (0:0) |
| Asunción |
Copa Sudamericana 2005, Section 5, First Stage |
| 23.08.2005 | | Cerro Porteño | – | Guaraní | | 1:2 (0:2),
pen. 4:3 |
| Asunción |
Copa Sudamericana 2005, Section 5, First Stage |
| 09.08.2005 | | Guaraní | – | Cerro Porteño | | 1:2 (0:2) |
| Asunción |
Copa Sudamericana 2003, Section 6, First Stage |
| 28.08.2003 | | Libertad | – | Guaraní | | 0:1 (0:1),
pen. 4:2 |
| Asunción |
Copa Sudamericana 2003, Section 6, First Stage |
| 14.08.2003 | | Guaraní | – | Libertad | | 0:1 (0:1) |
| Asunción |
