Copa Libertadores 2019, Third qualifying stage |
 | 27.02.2019 |  | Atlético Mineiro | – | Defensor Sporting |  | 0:0 |
| Belo Horizonte |
Copa Libertadores 2018, Group 1 |
| 27.02.2018 | | Defensor Sporting | – | Grêmio | | 1:1 (0:0) |
| Montevideo |
Copa Libertadores 2014, Group 5 |
| 09.04.2014 | | Defensor Sporting | – | Universidad de Chile |  | 1:1 (0:1) |
| Montevideo |
Copa Libertadores 2014, Group 5 |
| 20.03.2014 | | Cruzeiro | – | Defensor Sporting | | 2:2 (1:0) |
| Belo Horizonte |
Copa Libertadores 2013, Preliminary Round |
| 24.01.2013 | | Defensor Sporting | – | Olimpia |  | 0:0 |
| Montevideo |
Copa Libertadores 2009, 1/8 finals |
| 14.05.2009 | | Defensor Sporting | – | Boca Juniors |  | 2:2 (1:1) |
| Montevideo |
Copa Libertadores 2009, Group 4 |
| 16.04.2009 |  | América de Cali | – | Defensor Sporting | | 0:0 |
| Santiago de Cali |
Copa Libertadores 2009, Group 4 |
| 24.02.2009 | | Independiente Medellín | – | Defensor Sporting | | 0:0 |
| Medellín |
Copa Libertadores 2006, Preliminary Round |
| 02.02.2006 | | Santa Fe | – | Defensor Sporting | | 0:0 |
| Bogotá |
Copa Libertadores 2006, Preliminary Round |
| 27.01.2006 | | Defensor Sporting | – | Santa Fe | | 2:2 (0:1) |
| Montevideo |
Copa Libertadores 2001, Group 7 |
| 06.04.2001 | | São Caetano | – | Defensor Sporting | | 0:0 |
| São Caetano do Sul |
Copa Libertadores 1996, Group 2 |
| 17.04.1996 | | Defensor Sporting | – | Sporting Cristal |  | 0:0 |
| Montevideo |
Copa Libertadores 1996, Group 2 |
| 07.04.1996 | | Peñarol | – | Defensor Sporting | | 1:1 (0:0) |
| Montevideo |
Copa Libertadores 1996, Group 2 |
| 02.04.1996 | | Sporting Cristal | – | Defensor Sporting | | 0:0 |
| Lima |
Copa Libertadores 1996, Group 2 |
| 30.03.1996 | | Universitario de Deportes | – | Defensor Sporting | | 1:1 (0:0) |
| Lima |
Copa Libertadores 1994, 1/8 finals |
| 27.04.1994 | | Vélez Sársfield | – | Defensor Sporting | | 0:0,
pen. 4:2 |
| Buenos Aires |
Copa Libertadores 1994, 1/8 finals |
| 21.04.1994 | | Defensor Sporting | – | Vélez Sársfield | | 1:1 (1:1) |
| Montevideo |
Copa Libertadores 1994, Group 4 |
| 12.04.1994 | | Defensor Sporting | – | Unión Española | | 1:1 (1:1) |
| Montevideo |
Copa Libertadores 1994, Group 4 |
| 05.04.1994 | | Defensor Sporting | – | Colo-Colo | | 0:0 |
| Montevideo |
Copa Libertadores 1994, Group 4 |
| 23.03.1994 | | Nacional Montevideo | – | Defensor Sporting | | 1:1 (0:0) |
| Montevideo |
Copa Libertadores 1992, 1/8 finals |
| 29.04.1992 | | Defensor Sporting | – | Newell's Old Boys | | 1:1 (0:0) |
| Montevideo |
Copa Libertadores 1992, Group 5 |
| 09.04.1992 | | Sol de América | – | Defensor Sporting | | 0:0 |
| Asunción |
Copa Libertadores 1992, Group 5 |
| 01.04.1992 | | Cerro Porteño | – | Defensor Sporting | | 1:1 |
| Asunción |
Copa Libertadores 1990, Group 4 |
| 21.03.1990 | | Progreso | – | Defensor Sporting | | 1:1 (1:0) |
| Montevideo |
Copa Libertadores 1990, Group 4 |
| 14.03.1990 |  | Mineros | – | Defensor Sporting | | 0:0 |
| Puerto Ordaz |
Copa Libertadores 1990, Group 4 |
| 25.02.1990 | | Defensor Sporting | – | Progreso | | 0:0 |
| Montevideo |
Copa Libertadores 1982, First Round, Group 2 |
| 09.09.1982 | | Defensor Sporting | – | Peñarol | | 0:0 |
| Montevideo |
Copa Libertadores 1982, First Round, Group 2 |
| 24.08.1982 | | Defensor Sporting | – | Grêmio | | 0:0 |
| Montevideo |
Copa Libertadores 1980, First Round, Group 2 |
| 30.04.1980 | | Defensor Sporting | – | Oriente Petrolero |  | 1:1 (1:0) |
| Montevideo |
Copa Libertadores 1980, First Round, Group 2 |
| 27.04.1980 | | Defensor Sporting | – | The Strongest | | 1:1 (1:0) |
| Montevideo |
Copa Libertadores 1977, First Round, Group 1 |
| 12.05.1977 | | Defensor Sporting | – | River Plate | | 0:0 |
| Montevideo |
Copa Libertadores 1977, First Round, Group 1 |
| 21.04.1977 | | River Plate | – | Defensor Sporting | | 1:1 (0:1) |
| Buenos Aires |
Copa Libertadores 1977, First Round, Group 1 |
| 14.04.1977 | | Defensor Sporting | – | Boca Juniors | | 0:0 |
| Montevideo |
