Copa do Brasil 2024, Second round |
 | 13.03.2024 |  | América (Natal) | – | São Luiz (Ijuí) | | 3:0 (1:0) |
| Natal |
Copa do Brasil 2024, First Round |
| 21.02.2024 | | Costa Rica (Costa Rica) | – | América (Natal) | | 1:2 (0:1) |
| Costa Rica |
Copa do Brasil 2021, First Round |
| 11.03.2021 | | Real Brasília (Vila Planalto) | – | América (Natal) | | 0:2 (0:0) * |
| Luziânia |
Copa do Brasil 2016, First Round |
| 25.05.2016 | | América (Natal) | – | Gama (Brasília) | | 3:2 (3:2) |
| Natal |
Copa do Brasil 2015, Second round |
| 12.05.2015 | | América (Natal) | – | Atlético Goianiense (Goiânia) | | 4:2 (3:0) |
| Natal |
Copa do Brasil 2015, First Round |
| 01.04.2015 | | Globo (Ceará-Mirim) | – | América (Natal) | | 1:5 (0:1) |
| Ceará-Mirim |
Copa do Brasil 2014, Round of 16 |
| 27.08.2014 | | América (Natal) | – | Atlético Paranaense (Curitiba) | | 3:0 (2:0) |
| Natal |
Copa do Brasil 2014, Third round |
| 13.08.2014 | | Fluminense (Rio de Janeiro) | – | América (Natal) | | 2:5 (2:1) |
| Rio de Janeiro |
Copa do Brasil 2014, Second round |
| 06.05.2014 | | América (Natal) | – | Náutico (Recife) | | 3:0 (1:0) |
| Natal |
Copa do Brasil 2014, First Round |
| 23.04.2014 | | América (Natal) | – | Boavista (Saquarema) | | 2:0 (0:0) |
| Natal |
Copa do Brasil 2014, First Round |
| 02.04.2014 | | Boavista (Saquarema) | – | América (Natal) | | 1:2 (0:2) |
| Saquarema |
Copa do Brasil 2013, First Round |
| 25.04.2013 | | América (Natal) | – | Ji Paraná (Ji Paraná) | | 1:0 (0:0) |
| Goianinha |
Copa do Brasil 2013, First Round |
| 10.04.2013 | | Ji Paraná (Ji Paraná) | – | América (Natal) | | 0:1 (0:1) |
| Ji Paraná |
Copa do Brasil 2012, First Round |
| 14.03.2012 | | América (Natal) | – | Horizonte (Horizonte) | | 2:0 (1:0),
pen. 2:4 |
| Goianinha |
Copa do Brasil 2007, Second round |
| 04.04.2007 | | Fluminense (Rio de Janeiro) | – | América (Natal) | | 0:1 (0:0) |
| Rio de Janeiro |
Copa do Brasil 2007, First Round |
| 21.02.2007 | | América (Natal) | – | Baré (Boa Vista) | | 2:0 (1:0) |
| Mossoró |
Copa do Brasil 2004, First Round |
| 03.03.2004 | | América (Natal) | – | Ferroviário (Fortaleza) | | 1:0 (1:0) |
| Natal |
Copa do Brasil 2003, Second round |
| 26.03.2003 | | América (Natal) | – | Náutico (Recife) | | 2:1 (0:1) |
| Natal |
Copa do Brasil 2003, First Round |
| 12.03.2003 | | América (Natal) | – | Guarani (Venâncio Aires) | | 1:0 (1:0) |
| Natal |
Copa do Brasil 2002, First Round |
| 20.02.2002 | | América (Natal) | – | São Raimundo (Manaus) | | 2:0 (1:0) |
| Natal |
Copa do Brasil 2000, Third round |
| 10.05.2000 | | América (Natal) | – | Remo (Belém) | | 6:2 (2:1) |
| Natal |
Copa do Brasil 2000, Second round |
| 12.04.2000 | | América (Natal) | – | Sampaio Correa (São Luis) | | 2:1 (1:0) |
| Natal |
Copa do Brasil 2000, First Round |
| 29.03.2000 | | Sport (Recife) | – | América (Natal) | | 0:1 (0:0),
pen. 2:4 |
| Recife |
Copa do Brasil 1999, First Round |
| 04.03.1999 | | América (Natal) | – | CRB (Maceió) | | 2:1 (1:1) |
| Natal |
Copa do Brasil 1997, First Round |
| 13.03.1997 | | América (Natal) | – | Portuguesa (São Paulo) | | 1:0 (1:0) |
| Natal |
Copa do Brasil 1990, First Round |
| 27.06.1990 | | América (Natal) | – | Santa Cruz (Recife) | | 1:0 (0:0) |
| Natal |
