Copa Libertadores 2024, First Round |
 | 13.02.2024 |  | Defensor Sporting | – | Academia |  | 1:0 (1:0),
pen. 2:4 |
| Montevideo |
Copa Libertadores 2019, Second qualifying stage |
| 06.02.2019 | | Defensor Sporting | – | Barcelona |  | 3:0 |
| Montevideo |
Copa Libertadores 2019, First qualifying stage |
| 23.01.2019 |  | Bolívar | – | Defensor Sporting | | 2:4 (0:1) |
| La Paz |
Copa Libertadores 2018, Group 1 |
| 17.04.2018 | | Defensor Sporting | – | Monagas | | 3:1 (0:0) |
| Montevideo |
Copa Libertadores 2014, Semifinal |
| 29.07.2014 | | Defensor Sporting | – | Nacional Asunción |  | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 2014, Quarterfinal |
| 15.05.2014 | | Defensor Sporting | – | Atlético Nacional |  | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 2014, Quarterfinal |
| 08.05.2014 | | Atlético Nacional | – | Defensor Sporting | | 0:2 (0:0) |
| Medellín |
Copa Libertadores 2014, Round of 16 |
| 29.04.2014 | | Defensor Sporting | – | The Strongest | | 2:0 (0:0),
pen. 4:2 |
| Montevideo |
Copa Libertadores 2014, Group 5 |
| 01.04.2014 |  | Real Garcilaso | – | Defensor Sporting | | 0:2 (0:0) |
| Huancayo |
Copa Libertadores 2014, Group 5 |
| 11.03.2014 | | Defensor Sporting | – | Cruzeiro |  | 2:0 (0:0) |
| Montevideo |
Copa Libertadores 2014, Group 5 |
| 19.02.2014 | | Defensor Sporting | – | Real Garcilaso | | 4:1 (1:1) |
| Montevideo |
Copa Libertadores 2012, Group 7 |
| 17.04.2012 |  | Vélez Sársfield | – | Defensor Sporting | | 1:3 (0:2) |
| Buenos Aires |
Copa Libertadores 2012, Group 7 |
| 28.03.2012 | | Defensor Sporting | – | Guadalajara |  | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 2012, Group 7 |
| 14.02.2012 | | Defensor Sporting | – | Deportivo Quito | | 2:0 (1:0) |
| Montevideo |
Copa Libertadores 2009, 1/8 finals |
| 21.05.2009 | | Boca Juniors | – | Defensor Sporting | | 0:1 (0:1) |
| Buenos Aires |
Copa Libertadores 2009, Group 4 |
| 22.04.2009 | | Defensor Sporting | – | Independiente Medellín | | 4:3 (2:1) |
| Montevideo |
Copa Libertadores 2009, Group 4 |
| 10.02.2009 | | Defensor Sporting | – | América de Cali | | 1:0 (1:0) |
| Montevideo |
Copa Libertadores 2007, Quarterfinal |
| 16.05.2007 | | Defensor Sporting | – | Grêmio | | 2:0 (2:0) |
| Montevideo |
Copa Libertadores 2007, 1/8 finals |
| 02.05.2007 | | Defensor Sporting | – | Flamengo | | 3:0 (1:0) |
| Montevideo |
Copa Libertadores 2007, Group 8 |
| 28.03.2007 | | Defensor Sporting | – | Deportivo Pasto | | 3:0 (2:0) |
| Montevideo |
Copa Libertadores 2007, Group 8 |
| 15.03.2007 | | Deportivo Pasto | – | Defensor Sporting | | 1:2 (0:1) |
| Pasto |
Copa Libertadores 2007, Group 8 |
| 13.02.2007 | | Defensor Sporting | – | Gimnasia y Esgrima | | 3:0 (1:0) |
| Montevideo |
Copa Libertadores 2001, Group 7 |
| 12.04.2001 | | Defensor Sporting | – | Cruz Azul | | 3:2 (1:0) |
| Montevideo |
Copa Libertadores 2001, Group 7 |
| 14.02.2001 | | Defensor Sporting | – | Olmedo | | 3:2 (1:1) |
| Montevideo |
Copa Libertadores 1996, 1/8 finals |
| 09.05.1996 | | Defensor Sporting | – | Universidad de Chile |  | 2:1 (1:1),
pen. 6:7 |
| Montevideo |
Copa Libertadores 1996, Group 2 |
| 12.04.1996 | | Defensor Sporting | – | Universitario de Deportes | | 2:0 (2:0) |
| Montevideo |
Copa Libertadores 1994, Group 4 |
| 02.03.1994 | | Defensor Sporting | – | Nacional Montevideo | | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 1992, Group 5 |
| 25.03.1992 | | Nacional Montevideo | – | Defensor Sporting | | 2:3 |
| Montevideo |
Copa Libertadores 1990, Group 4 |
| 29.03.1990 | | Defensor Sporting | – | Mineros | | 3:1 (2:0) |
| Montevideo |
Copa Libertadores 1990, Group 4 |
| 26.03.1990 | | Defensor Sporting | – | Pepeganga Margarita | | 1:0 (1:0) |
| Montevideo |
Copa Libertadores 1982, First Round, Group 2 |
| 24.09.1982 | | Grêmio | – | Defensor Sporting | | 1:2 (0:1) |
| Porto Alegre |
Copa Libertadores 1980, First Round, Group 2 |
| 16.04.1980 | | Oriente Petrolero | – | Defensor Sporting | | 0:1 (0:1) |
| Santa Cruz de la Sierra |
Copa Libertadores 1977, First Round, Group 1 |
| 31.03.1977 | | Peñarol | – | Defensor Sporting | | 0:2 (0:0) |
| Montevideo |
