Copa Libertadores 2023, Group B |
 | 28.06.2023 |  | Internacional | – | Independiente |  | 3:1 (3:0) |
| Porto Alegre |
Copa Libertadores 2023, Group B |
| 19.04.2023 |  | Nacional | – | Independiente | | 2:1 (1:0) |
| Montevideo |
Copa Libertadores 2020, Group H |
| 24.09.2020 | | Independiente | – | Boca Juniors |  | 0:1 (0:0) |
| Medellín |
Copa Libertadores 2020, Group H |
| 16.09.2020 | | Independiente | – | Caracas |  | 2:3 (1:2) |
| Medellín |
Copa Libertadores 2020, Group H |
| 10.03.2020 | | Boca Juniors | – | Independiente | | 3:0 (1:0) |
| Buenos Aires |
Copa Libertadores 2020, Group H |
| 03.03.2020 | | Independiente | – | Libertad |  | 1:2 (0:2) |
| Medellín |
Copa Libertadores 2020, Third qualifying stage |
| 25.02.2020 | | Atlético Tucumán | – | Independiente | | 1:0 (1:0),
pen. 2:4 |
| San Miguel de Tucumán |
Copa Libertadores 2020, Second qualifying stage |
| 11.02.2020 | | Deportivo Táchira | – | Independiente | | 2:0 (1:0) |
| San Cristóbal |
Copa Libertadores 2017, Group 3 |
| 16.05.2017 | | Independiente | – | Emelec |  | 1:2 (1:2) |
| Medellín |
Copa Libertadores 2017, Group 3 |
| 13.04.2017 | | Emelec | – | Independiente | | 1:0 (0:0) |
| Guayaquil |
Copa Libertadores 2017, Group 3 |
| 15.03.2017 | | Independiente | – | River Plate | | 1:3 (0:2) |
| Medellín |
Copa Libertadores 2010, Group 1 |
| 22.04.2010 | | Corinthians | – | Independiente Medellín | | 1:0 (1:0) |
| São Paulo |
Copa Libertadores 2010, Group 1 |
| 25.03.2010 | | Racing | – | Independiente Medellín | | 1:0 (0:0) |
| Montevideo |
Copa Libertadores 2009, Group 4 |
| 22.04.2009 | | Defensor Sporting | – | Independiente Medellín | | 4:3 (2:1) |
| Montevideo |
Copa Libertadores 2005, 1/8 finals |
| 24.05.2005 | | Independiente Medellín | – | Banfield | | 0:2 (0:0) |
| Medellín |
Copa Libertadores 2005, 1/8 finals |
| 18.05.2005 | | Banfield | – | Independiente Medellín | | 3:0 (0:0) |
| Buenos Aires |
Copa Libertadores 2005, Group 1 |
| 08.03.2005 | | Libertad | – | Independiente Medellín | | 3:2 (3:1) |
| Asunción |
Copa Libertadores 2005, Group 1 |
| 22.02.2005 | | América de Cali | – | Independiente Medellín | | 1:0 (0:0) |
| Santiago de Cali |
Copa Libertadores 2003, Semifinal |
| 18.06.2003 | | Independiente Medellín | – | Santos | | 2:3 (1:1) |
| Medellín |
Copa Libertadores 2003, Semifinal |
| 04.06.2003 | | Santos | – | Independiente Medellín | | 1:0 (0:0) |
| Santos |
Copa Libertadores 2003, 1/8 finals |
| 06.05.2003 | | Independiente Medellín | – | Cerro Porteño | | 0:1 aet
(0:0, 0:1),
pen. 4:2 |
| Medellín |
Copa Libertadores 2003, Group 7 |
| 06.03.2003 |  | Colo-Colo | – | Independiente Medellín | | 2:1 (1:1) |
| Santiago |
Copa Libertadores 2003, Group 7 |
| 20.02.2003 | | Boca Juniors | – | Independiente Medellín | | 2:0 (0:0) |
| Buenos Aires |
Copa Libertadores 1994, Quarterfinal |
| 27.07.1994 | | Independiente Medellín | – | Junior | | 0:2 (0:0) |
| Medellín |
Copa Libertadores 1994, 1/8 finals |
| 20.04.1994 |  | Universitario de Deportes | – | Independiente Medellín | | 2:1 (0:0) |
| Lima |
Copa Libertadores 1994, Group 1 |
| 24.03.1994 | | Independiente Medellín | – | Junior | | 0:1 (0:1) |
| Medellín |
Copa Libertadores 1967, First Round, Group 2 |
| 14.05.1967 | | Independiente Medellín | – | Santa Fe | | 0:4 (0:2) |
| Medellín |
Copa Libertadores 1967, First Round, Group 2 |
| 20.04.1967 | | River Plate | – | Independiente Medellín | | 6:2 (2:1) |
| Avellaneda |
Copa Libertadores 1967, First Round, Group 2 |
| 18.04.1967 | | Racing Club | – | Independiente Medellín | | 5:2 (3:0) |
| Buenos Aires |
Copa Libertadores 1967, First Round, Group 2 |
| 05.04.1967 | | Independiente Medellín | – | River Plate | | 0:1 (0:0) |
| Medellín |
Copa Libertadores 1967, First Round, Group 2 |
| 26.03.1967 | | Independiente Medellín | – | Racing Club | | 0:2 (0:0) |
| Medellín |
Copa Libertadores 1967, First Round, Group 2 |
| 19.02.1967 | | Santa Fe | – | Independiente Medellín | | 2:0 (1:0) |
| Bogotá |
