CAF Champions League 2022/23, First Round |
 | 12.09.2022 |  | RC Kadiogo | – | Asante Kotoko |  | 0:1 (0:0) |
| Benin, Cotonou |
CAF Champions League 2020/21, Preliminary Round |
| 06.12.2020 | | Asante Kotoko | – | FC Nouadhibou |  | 2:0 |
| Accra |
CAF Champions League 2019/20, First Round |
| 15.09.2019 | | Asante Kotoko FC | – | Étoile du Sahel |  | 2:0 (1:0) |
| Kumasi |
CAF Champions League 2019/20, Preliminary Round |
| 25.08.2019 | | Asante Kotoko FC | – | Kano Pillars |  | 2:0 (1:0) |
| Kumasi |
CAF Champions League 2015, Preliminary Round |
| 13.02.2015 |  | East End Lions | – | Asante Kotoko | | -:+ |
| |
CAF Champions League 2014, Preliminary Round |
| 09.02.2014 | | Asante Kotoko | – | Barrack Young Controllers |  | 2:1 (1:1) |
| Kumasi |
CAF Champions League 2013, Preliminary Round |
| 03.03.2013 |  | Elá Nguema | – | Asante Kotoko | | 0:1 (0:0) |
| Malabo |
CAF Champions League 2013, Preliminary Round |
| 17.02.2013 | | Asante Kotoko | – | Elá Nguema | | 7:0 (4:0) |
| Kumasi |
CAF Champions League 2010, Preliminary Round |
| 28.02.2010 | | Asante Kotoko | – | Linguère |  | 2:0 (1:0),
pen. 2:4 |
| Kumasi |
CAF Champions League 2009, 1/16 Finals |
| 15.03.2009 | | Asante Kotoko | – | IZ Khémisset |  | 3:1 (1:1) |
| Sekondi-Takoradi |
CAF Champions League 2007, Preliminary Round |
| 03.02.2007 | | Asante Kotoko | – | Ports Authority |  | 1:0 (0:0) |
| Obuasi |
CAF Champions League 2006, Group A |
| 09.09.2006 | | Asante Kotoko | – | Kabylie |  | 2:1 |
| Obuasi |
CAF Champions League 2006, Group A |
| 29.07.2006 | | Asante Kotoko | – | Sfaxien | | 4:2 |
| Obuasi |
CAF Champions League 2006, 1/8 Finals |
| 23.04.2006 | | Asante Kotoko | – | USCAFOOT |  | 6:0 |
| |
CAF Champions League 2006, 1/16 Finals |
| 02.04.2006 | | Asante Kotoko | – | Ferroviário |  | 2:1 |
| |
CAF Champions League 2006, Preliminary Round |
| 05.03.2006 | | Asante Kotoko | – | Aigle Royal de la Menoua |  | 3:0 (1:0) |
| |
CAF Champions League 2005, 1/16 Finals |
| 06.03.2005 | | Asante Kotoko | – | FAR | | 1:0 (0:0) |
| |
CAF Champions League 2005, Preliminary Round |
| 30.01.2005 | | Asante Kotoko | – | Wallidan | | +:- |
| |
CAF Champions League 2004, 1/8 Finals |
| 30.05.2004 | | Asante Kotoko | – | USM Alger | | 2:0 (1:0),
pen. 1:3 |
| |
CAF Champions League 2004, Preliminary Round |
| 07.03.2004 | | Asante Kotoko | – | Tempête Mocaf |  | +:- |
| |
African Cup of Champions Clubs 1983, Final |
| 11.12.1983 | | Asante Kotoko | – | Al Ahly Cairo |  | 1:0 (1:0) |
| Kumasi |
African Cup of Champions Clubs 1973, Final |
| 25.11.1973 | | Asante Kotoko | – | Vita |  | 4:2 (1:1) |
| Kumasi |
African Cup of Champions Clubs 1971, Final |
| 05.12.1971 | | Asante Kotoko | – | Canon | | 3:0 |
| Kumasi |
African Cup of Champions Clubs 1970/71, Final |
| 24.01.1971 | | TP Englebert | – | Asante Kotoko | | 1:2 (1:1) |
| Kinshasa |
African Cup of Champions Clubs 1993, First Round |
| | | Asante Kotoko | – | Sahel |  | 2:0 |
| |
African Cup of Champions Clubs 1993, Second Round |
| | | Asante Kotoko | – | KAC | | 3:0 |
| |
African Cup of Champions Clubs 1993, Quarterfinal |
| | | Asante Kotoko | – | Nkana Red Devils |  | 3:0 |
| |
African Cup of Champions Clubs 1993, Semifinal |
| | | Asante Kotoko | – | ASEC |  | 2:0 |
| |
African Cup of Champions Clubs 1992, First Round |
| | | Asante Kotoko | – | Mikishi | | 2:0 |
| |
African Cup of Champions Clubs 1992, Second Round |
| | | Costa do Sol | – | Asante Kotoko | | 1:2 |
| |
African Cup of Champions Clubs 1992, Second Round |
| | | Asante Kotoko | – | Costa do Sol | | 2:1 |
| |
African Cup of Champions Clubs 1992, Quarterfinal |
| | | ASEC | – | Asante Kotoko | | 1:2 |
| |
African Cup of Champions Clubs 1990, First Round |
| | | Asante Kotoko | – | Freetown United | | 4:0 |
| |
African Cup of Champions Clubs 1990, Second Round |
| | | Asante Kotoko | – | FAR | | 1:0 |
| |
African Cup of Champions Clubs 1990, Quarterfinal |
| | | Asante Kotoko | – | Al Hilal |  | 2:1 |
| |
African Cup of Champions Clubs 1990, Semifinal |
| | | Asante Kotoko | – | Kabylie | | 1:0 |
| |
African Cup of Champions Clubs 1988, First Round |
| | | Asante Kotoko | – | FC 105 |  | 2:0 |
| |
African Cup of Champions Clubs 1987, First Round |
| | | Asante Kotoko | – | Sporting Clube |  | +:- |
| |
African Cup of Champions Clubs 1987, Second Round |
| | | Asante Kotoko | – | WAC Casablanca | | 2:0 |
| |
African Cup of Champions Clubs 1987, Quarterfinal |
| | | Asante Kotoko | – | Zamalek | | 5:1 |
| |
African Cup of Champions Clubs 1987, Semifinal |
| | | Asante Kotoko | – | Al Ahly Cairo | | 1:0 |
| |
African Cup of Champions Clubs 1983, First Round |
| | | FC 105 | – | Asante Kotoko | | 1:2 |
| |
African Cup of Champions Clubs 1983, First Round |
| | | Asante Kotoko | – | FC 105 | | 2:0 |
| |
African Cup of Champions Clubs 1983, Second Round |
| | | Asante Kotoko | – | CARA |  | 2:0 |
| |
African Cup of Champions Clubs 1983, Quarterfinal |
| | | Asante Kotoko | – | Bilima | | 3:0 |
| |
African Cup of Champions Clubs 1983, Semifinal |
| | | Asante Kotoko | – | Diaraf | | 2:0 |
| |
African Cup of Champions Clubs 1982, First Round |
| | | Asante Kotoko | – | Semassi |  | 2:0 |
| |
African Cup of Champions Clubs 1982, Second Round |
| | | Asante Kotoko | – | Invincible Eleven | | 3:0 |
| |
African Cup of Champions Clubs 1982, Quarterfinal |
| | | Asante Kotoko | – | Kampala City Council |  | 6:0 |
| |
African Cup of Champions Clubs 1982, Semifinal |
| | | Lupopo | – | Asante Kotoko | | 1:2 |
| |
African Cup of Champions Clubs 1982, Semifinal |
| | | Asante Kotoko | – | Lupopo | | 2:0 |
| |
African Cup of Champions Clubs 1981, First Round |
| | | Asante Kotoko | – | Invincible Eleven | | 3:0 |
| |
African Cup of Champions Clubs 1981, Second Round |
| | | Asante Kotoko | – | Kaloum Star |  | 1:0 |
| |
African Cup of Champions Clubs 1976, First Round |
| | | Asante Kotoko | – | Okoume | | +:- |
| |
African Cup of Champions Clubs 1976, Second Round |
| | | Asante Kotoko | – | CARA | | 1:0 |
| |
African Cup of Champions Clubs 1976, Quarterfinal |
| | | Asante Kotoko | – | ASEC | | 2:1 |
| |
African Cup of Champions Clubs 1973, Second Round |
| | | Asante Kotoko | – | Al Merreikh | | 3:0 |
| |
African Cup of Champions Clubs 1973, Quarterfinal |
| | | Asante Kotoko | – | Kabwe Warriors | | 2:0 |
| |
African Cup of Champions Clubs 1973, Semifinal |
| |  | Breweries | – | Asante Kotoko | | 0:2 |
| |
African Cup of Champions Clubs 1973, Semifinal |
| | | Asante Kotoko | – | Breweries | | 2:1 |
| |
African Cup of Champions Clubs 1971, Second Round |
| | | Asante Kotoko | – | Al Merreikh | | 1:0 aet,
pen. 5:4 |
| |
African Cup of Champions Clubs 1971, Quarterfinal |
| | | Asante Kotoko | – | Ismaily | | 3:0 |
| |
African Cup of Champions Clubs 1971, Semifinal |
| | | Asante Kotoko | – | Great Olympics | | 1:0 |
| |
African Cup of Champions Clubs 1970/71, Second Round |
| | | Asante Kotoko | – | Stationery Stores | | 1:0 |
| |
African Cup of Champions Clubs 1970/71, Quarterfinal |
| | | Asante Kotoko | – | Young Africans |  | 2:0 |
| |
African Cup of Champions Clubs 1970/71, Semifinal |
| | | Asante Kotoko | – | Ismaily | | 2:0 |
| |
African Cup of Champions Clubs 1969/70, First Round |
| | | Asante Kotoko | – | Patronage Sainte Anne | | 5:1 |
| |
African Cup of Champions Clubs 1967, First Round |
| | | Saint Louisienne | – | Asante Kotoko | | 2:3 |
| |
African Cup of Champions Clubs 1967, First Round |
| | | Asante Kotoko | – | Saint Louisienne | | 3:0 |
| |
African Cup of Champions Clubs 1967, Quarterfinal |
| | | Stade | – | Asante Kotoko | | 1:3 |
| |
African Cup of Champions Clubs 1967, Quarterfinal |
| | | Asante Kotoko | – | Stade | | 5:2 |
| |
African Cup of Champions Clubs 1967, Semifinal |
| |  | Djoliba | – | Asante Kotoko | | 1:2 |
| |
African Cup of Champions Clubs 1966, First Round |
| | | Etoile Filante | – | Asante Kotoko | | 0:3 |
| |
African Cup of Champions Clubs 1966, First Round |
| | | Asante Kotoko | – | Etoile Filante | | 3:0 |
| |
