CAF Champions League 2022/23, First Round |
 | 18.09.2022 |  | Asante Kotoko | – | RC Kadiogo |  | 0:1 (0:1),
pen. 1:3 |
| Kumasi |
CAF Champions League 2020/21, First Round |
| 06.01.2021 |  | Al Hilal | – | Asante Kotoko | | 2:0 |
| Omdurman |
CAF Champions League 2020/21, First Round |
| 23.12.2020 | | Asante Kotoko | – | Al Hilal | | 0:1 (0:0) |
| Accra |
CAF Champions League 2019/20, First Round |
| 29.09.2019 |  | Étoile du Sahel | – | Asante Kotoko FC | | 3:0 (1:0) |
| Monastir |
CAF Champions League 2019/20, Preliminary Round |
| 10.08.2019 |  | Kano Pillars | – | Asante Kotoko FC | | 3:2 (1:0) |
| Kano |
CAF Champions League 2015, Round of 32 |
| 05.04.2015 | | Asante Kotoko | – | El Eulma |  | 1:2 (1:0) |
| Kumasi |
CAF Champions League 2014, Preliminary Round |
| 16.02.2014 |  | Barrack Young Controllers | – | Asante Kotoko | | 1:0 (0:0) |
| Monrovia |
CAF Champions League 2010, Preliminary Round |
| 13.02.2010 |  | Linguère | – | Asante Kotoko | | 2:0 (0:0) |
| Saint-Louis |
CAF Champions League 2009, 1/16 Finals |
| 05.04.2009 |  | IZ Khémisset | – | Asante Kotoko | | 2:0 (0:0) |
| Khemisset |
CAF Champions League 2007, Preliminary Round |
| 11.02.2007 |  | Ports Authority | – | Asante Kotoko | | 1:0,
pen. 4:2 |
| |
CAF Champions League 2006, Group A |
| 17.09.2006 | | Sfaxien | – | Asante Kotoko | | 2:1 |
| |
CAF Champions League 2006, Group A |
| 26.08.2006 |  | Al Ahly Cairo | – | Asante Kotoko | | 4:0 |
| |
CAF Champions League 2006, Group A |
| 16.07.2006 | | Kabylie | – | Asante Kotoko | | 1:0 |
| Alger |
CAF Champions League 2006, 1/8 Finals |
| 07.05.2006 |  | USCAFOOT | – | Asante Kotoko | | 1:0 (0:0) |
| |
CAF Champions League 2005, 1/16 Finals |
| 19.03.2005 | | FAR | – | Asante Kotoko | | 2:0 (2:0) |
| |
CAF Champions League 2004, 1/8 Finals |
| 15.05.2004 | | USM Alger | – | Asante Kotoko | | 2:0 (1:0) |
| |
African Cup of Champions Clubs 1982, Final |
| 28.11.1982 | | Al Ahly Cairo | – | Asante Kotoko | | 3:0 (3:0) |
| Cairo |
African Cup of Champions Clubs 1973, Final |
| 16.12.1973 |  | Vita | – | Asante Kotoko | | 3:0 |
| Kinshasa |
African Cup of Champions Clubs 1971, Final |
| 21.12.1971 |  | Canon | – | Asante Kotoko | | 1:0 |
| Yaoundé Stade Militaire Garoua |
African Cup of Champions Clubs 1971, Final |
| 19.12.1971 | | Canon | – | Asante Kotoko | | 2:0 |
| Yaoundé Stade Militaire Garoua |
African Cup of Champions Clubs 1967, Final |
| 27.12.1967 | | TP Englebert | – | Asante Kotoko | | +:- |
| Cameroon, Douala |
African Cup of Champions Clubs 1993, Second Round |
| | | KAC | – | Asante Kotoko | | 1:0 |
| |
African Cup of Champions Clubs 1993, Quarterfinal |
| |  | Nkana Red Devils | – | Asante Kotoko | | 1:0 |
| |
African Cup of Champions Clubs 1993, Semifinal |
| |  | ASEC | – | Asante Kotoko | | 3:1 |
| |
African Cup of Champions Clubs 1992, Quarterfinal |
| | | Asante Kotoko | – | ASEC | | 2:3 |
| |
African Cup of Champions Clubs 1990, Semifinal |
| | | Kabylie | – | Asante Kotoko | | 2:0 |
| |
African Cup of Champions Clubs 1988, First Round |
| |  | FC 105 | – | Asante Kotoko | | 2:0 aet,
pen. 4:2 |
| |
African Cup of Champions Clubs 1987, Quarterfinal |
| | | Zamalek | – | Asante Kotoko | | 2:0 |
| |
African Cup of Champions Clubs 1987, Semifinal |
| | | Al Ahly Cairo | – | Asante Kotoko | | 2:0 |
| |
African Cup of Champions Clubs 1984, First Round |
| |  | Primeiro de Maio | – | Asante Kotoko | | 2:1 |
| |
African Cup of Champions Clubs 1983, Second Round |
| |  | CARA | – | Asante Kotoko | | 3:2 |
| |
African Cup of Champions Clubs 1983, Quarterfinal |
| | | Bilima | – | Asante Kotoko | | 2:0 |
| |
African Cup of Champions Clubs 1983, Semifinal |
| | | Diaraf | – | Asante Kotoko | | 2:1 |
| |
African Cup of Champions Clubs 1982, First Round |
| |  | Semassi | – | Asante Kotoko | | 3:2 |
| |
African Cup of Champions Clubs 1981, Second Round |
| |  | Kaloum Star | – | Asante Kotoko | | 3:1 |
| |
African Cup of Champions Clubs 1976, Second Round |
| | | CARA | – | Asante Kotoko | | 2:1 |
| |
African Cup of Champions Clubs 1976, Quarterfinal |
| | | ASEC | – | Asante Kotoko | | 1:0 |
| |
African Cup of Champions Clubs 1973, Quarterfinal |
| | | Kabwe Warriors | – | Asante Kotoko | | 2:1 |
| |
African Cup of Champions Clubs 1971, Second Round |
| | | Al Merreikh | – | Asante Kotoko | | 2:1 |
| |
African Cup of Champions Clubs 1970/71, Second Round |
| | | Stationery Stores | – | Asante Kotoko | | 3:2 |
| |
African Cup of Champions Clubs 1969/70, Semifinal |
| | | Ismaily | – | Asante Kotoko | | 3:2 |
| |
African Cup of Champions Clubs 1966, Quarterfinal |
| | | Asante Kotoko | – | Stade | | 0:1 |
| |
