Copa Libertadores 2022, Group E |
 | 04.05.2022 |  | Deportivo Cali | – | Corinthians |  | 0:0 |
| Santiago de Cali |
Copa Libertadores 2022, Group E |
| 28.04.2022 |  | Always Ready | – | Deportivo Cali | | 2:2 (2:1) |
| La Paz |
Copa Libertadores 2016, Group 3 |
| 14.04.2016 | | Deportivo Cali | – | Bolívar | | 1:1 (1:0) |
| Santiago de Cali |
Copa Libertadores 2016, Group 3 |
| 17.03.2016 | | Deportivo Cali | – | Racing Club |  | 2:2 (2:0) |
| Santiago de Cali |
Copa Libertadores 2016, Group 3 |
| 24.02.2016 | | Deportivo Cali | – | Boca Juniors | | 0:0 |
| Santiago de Cali |
Copa Libertadores 2014, Group 3 |
| 26.03.2014 | | Deportivo Cali | – | O'Higgins |  | 1:1 (0:0) |
| Santiago de Cali |
Copa Libertadores 2006, Group 4 |
| 11.04.2006 | | Deportivo Cali | – | Sinergia Deportiva |  | 2:2 (1:1) |
| Santiago de Cali |
Copa Libertadores 2003, 1/8 finals |
| 13.05.2003 | | Deportivo Cali | – | Cruz Azul | | 0:0,
pen. 2:3 |
| Santiago de Cali |
Copa Libertadores 2003, 1/8 finals |
| 06.05.2003 | | Cruz Azul | – | Deportivo Cali | | 0:0 |
| Ciudad de México |
Copa Libertadores 1999, Quarterfinal |
| 12.05.1999 |  | Bella Vista | – | Deportivo Cali | | 1:1 (0:0) |
| Maldonado |
Copa Libertadores 1997, Group 5 |
| 15.04.1997 | | Nacional Montevideo | – | Deportivo Cali | | 1:1 (1:1) |
| Montevideo |
Copa Libertadores 1997, Group 5 |
| 19.03.1997 | | Los Millonarios | – | Deportivo Cali | | 2:2 (2:0) |
| Bogotá |
Copa Libertadores 1987, First Round, Group 2 |
| 08.07.1987 | | América de Cali | – | Deportivo Cali | | 0:0 aet,
pen. 4:2 * |
| Santiago de Cali |
Copa Libertadores 1986, First Round, Group 2 |
| 22.04.1986 | | Cobresal | – | Deportivo Cali | | 1:1 (1:1) |
| El Salvador |
Copa Libertadores 1986, First Round, Group 2 |
| 21.03.1986 | | Deportivo Cali | – | Cobresal | | 1:1 (1:1) |
| Santiago de Cali |
Copa Libertadores 1986, First Round, Group 2 |
| 12.03.1986 | | América de Cali | – | Deportivo Cali | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1981, Semifinal group 1 |
| 27.10.1981 | | Jorge Wilstermann | – | Deportivo Cali | | 1:1 (1:0) |
| Cochabamba |
Copa Libertadores 1979, First Round, Group 1 |
| 14.03.1979 | | Los Millonarios | – | Deportivo Cali | | 1:1 (0:1) |
| Bogotá |
Copa Libertadores 1978, Final |
| 23.11.1978 | | Deportivo Cali | – | Boca Juniors | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1978, Semifinal group 2 |
| 17.09.1978 | | Deportivo Cali | – | Cerro Porteño |  | 1:1 (0:0) |
| Santiago de Cali |
Copa Libertadores 1978, First Round, Group 4 |
| 09.07.1978 | | Deportivo Cali | – | Junior | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1978, First Round, Group 4 |
| 12.04.1978 | | Junior | – | Deportivo Cali | | 0:0 |
| Barranquilla |
Copa Libertadores 1977, Semifinal group 1 |
| 16.08.1977 | | Boca Juniors | – | Deportivo Cali | | 1:1 (0:0) |
| Buenos Aires |
Copa Libertadores 1977, Semifinal group 1 |
| 03.08.1977 | | Deportivo Cali | – | Boca Juniors | | 1:1 (1:1) |
| Santiago de Cali |
Copa Libertadores 1977, Semifinal group 1 |
| 27.07.1977 | | Deportivo Cali | – | Libertad | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1975, First Round, Group 3 |
| 06.04.1975 | | Vasco da Gama | – | Deportivo Cali | | 0:0 |
| Rio de Janeiro |
Copa Libertadores 1975, First Round, Group 3 |
| 23.02.1975 | | Deportivo Cali | – | Atlético Nacional | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1973, First Round, Group 4 |
| 21.03.1973 | | Deportivo Cali | – | Los Millonarios | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1970, First Round, Group 3 |
| 24.03.1970 | | Guaraní Asunción | – | Deportivo Cali | | 1:1 (1:0) |
| Asunción |
Copa Libertadores 1970, First Round, Group 3 |
| 08.03.1970 | | Deportivo Cali | – | Guaraní Asunción | | 0:0 |
| Santiago de Cali |
Copa Libertadores 1969, Second round, group 2 |
| 16.04.1969 | | Santiago Wanderers | – | Deportivo Cali | | 3:3 (2:0) |
| Viña del Mar |
Copa Libertadores 1969, First Round, Group 1 |
| 26.02.1969 |  | Canarias | – | Deportivo Cali | | 1:1 (0:0) |
| Caracas |
Copa Libertadores 1969, First Round, Group 1 |
| 23.02.1969 | | Unión Magdalena | – | Deportivo Cali | | 2:2 (0:0) |
| Santa Marta |
Copa Libertadores 1968, First Round, Group 1 |
| 22.02.1968 | | Independiente Avellaneda | – | Deportivo Cali | | 1:1 (1:0) |
| Avellaneda |
