FA Cup 2024/25, First Qualifying Round |
 | 31.08.2024 |  | Newcastle Benfield | – | Prescot Cables | | 2:1 (1:1) |
| Newcastle upon Tyne |
FA Cup 2023/24, Second Qualifying Round |
| 16.09.2023 | | Whitby Town | – | Prescot Cables | | 2:1 (2:1) |
| Whitby |
FA Cup 2022/23, Second Qualifying Round |
| 17.09.2022 | | Prescot Cables | – | Bamber Bridge | | 1:2 (1:1) |
| Prescot |
FA Cup 2021/22, Second qualifying round |
| 18.09.2021 | | Prescot Cables | – | Whitby Town | | 0:3 (0:1) |
| Prescot |
FA Cup 2019/20, Preliminary Round |
| 24.08.2019 | | Northwich Victoria | – | Prescot Cables | | 2:1 (0:0) |
| Northwich |
FA Cup 2018/19, Preliminary Round |
| 25.08.2018 | | Prescot Cables | – | Irlam | | 1:2 (1:1) |
| Prescot |
FA Cup 2017/18, Preliminary Round |
| 22.08.2017 | | City of Liverpool | – | Prescot Cables | | 8:2 (4:1) * |
| Liverpool |
FA Cup 2016/17, Preliminary Round |
| 20.08.2016 | | Prescot Cables | – | Trafford | | 0:1 |
| Prescot |
FA Cup 2015/16, Preliminary Round |
| 29.08.2015 | | Glossop North End | – | Prescot Cables | | 2:1 |
| Glossop |
FA Cup 2014/15, First Qualifying Round |
| 14.09.2014 | | United of Manchester | – | Prescot Cables | | 4:1 (2:0) |
| Stalybridge |
FA Cup 2013/14, First Qualifying Round |
| 14.09.2013 | | Prescot Cables | – | Buxton | | 0:1 |
| Prescot |
FA Cup 2012/13, First Qualifying Round |
| 08.09.2012 | | Prescot Cables | – | Ashton United | | 1:3 (0:2) |
| Prescot |
FA Cup 2011/12, Preliminary Round |
| 03.09.2011 | | Prescot Cables | – | Warrington Town | | 0:2 |
| |
FA Cup 2010/11, First Qualifying Round |
| 13.09.2010 | | Ashton United | – | Prescot Cables | | 4:0 * |
| |
FA Cup 2009/10, Preliminary Round |
| 29.08.2009 | | Atherton Laburnum Rovers | – | Prescot Cables | | 1:0 |
| |
FA Cup 2008/09, Third Qualifying Round |
| 11.10.2008 | | Belper Town | – | Prescot Cables | | 4:1 (1:0) |
| |
FA Cup 2007/08, Second Qualifying Round |
| 02.10.2007 | | Guiseley | – | Prescot Cables | | 1:0 * |
| |
FA Cup 2006/07, Second Qualifying Round |
| 30.09.2006 | | Prescot Cables | – | Marine | | 1:2 |
| |
FA Cup 2005/06, Second Qualifying Round |
| 24.09.2005 | | Blyth Spartans | – | Prescot Cables | | 1:0 |
| |
FA Cup 2004/05, Second Qualifying Round |
| | | Liversedge | – | Prescot Cables | | 3:0 |
| |
FA Cup 2003/04, Preliminary Round |
| | | Bamber Bridge | – | Prescot Cables | | 3:1 |
| |
FA Cup 2002/03, Preliminary Round |
| | | Prescot Cables | – | Witton Albion | | 3:6 |
| |
FA Cup 2001/02, Extra Preliminary Round |
| | | Prescot Cables | – | Salford City | | 2:4 |
| |
FA Cup 2000/01, Preliminary Round |
| | | Prescot Cables | – | Bedlington Terriers | | 0:2 |
| |
FA Cup 1999/00, Preliminary Round |
| | | Bradford Park Avenue | – | Prescot Cables | | 1:0 |
| |
FA Cup 1998/99, Third Qualifying Round |
| | | Morpeth Town | – | Prescot Cables | | 1:0 |
| |
FA Cup 1995/96, First Qualifying Round |
| | | Prescot Cables | – | Frickley Athletic | | 0:1 * |
| |
FA Cup 1994/95, First Qualifying Round |
| | | Prescot | – | Nantwich Town | | 1:3 |
| |
FA Cup 1993/94, Preliminary Round |
| | | Winterton Rangers | – | Prescot | | 2:0 |
| |
FA Cup 1992/93, Preliminary Round |
| | | Great Harwood Town | – | Prescot | | 2:1 |
| |
FA Cup 1991/92, First Qualifying Round |
| | | Prescot | – | Accrington Stanley | | 0:5 |
| |
FA Cup 1990/91, Preliminary Round |
| | | Emley | – | Prescot | | 2:1 * |
| |
FA Cup 1989/90, First Qualifying Round |
| | | Curzon Ashton | – | Prescot Cables | | 2:0 |
| |
FA Cup 1988/89, First Qualifying Round |
| | | Eastwood Hanley | – | Prescot Cables | | 2:0 |
| |
FA Cup 1987/88, First Qualifying Round |
| | | Prescot Cables | – | Colwyn Bay |  | 0:1 |
| |
FA Cup 1986/87, Second Qualifying Round |
| | | Rossendale United | – | Prescot Cables | | 2:1 |
| |
FA Cup 1986/87, First Qualifying Round |
| | | Oswestry Town | – | Prescot Cables | | 1:0 * |
| |
FA Cup 1985/86, First Qualifying Round |
| | | Prescot Cables | – | Runcorn | | 1:2 |
| |
FA Cup 1984/85, Preliminary Round |
| | | Ashton United | – | Prescot Cables | | 3:1 * |
| |
FA Cup 1983/84, First Qualifying Round |
| | | Prescot Cables | – | Rhyl | | 0:5 |
| |
FA Cup 1982/83, Second Qualifying Round |
| | | Caernarfon Town | – | Prescot Cables | | 4:1 |
| |
FA Cup 1981/82, Third Qualifying Round |
| | | Runcorn | – | Prescot Cables | | 4:1 |
| |
FA Cup 1980/81, Third Qualifying Round |
| | | Burscough | – | Prescot Cables | | 4:0 |
| |
FA Cup 1979/80, Second Qualifying Round |
| | | Droylsden | – | Prescot Town | | 1:0 * |
| |
FA Cup 1978/79, First Qualifying Round |
| | | Rhyl | – | Prescot Town | | 2:0 |
| |
FA Cup 1977/78, First Qualifying Round |
| | | Prescot Town | – | Darwen | | 0:1 |
| |
FA Cup 1976/77, First Qualifying Round |
| | | Bangor City | – | Prescot Town | | 6:0 |
| |
FA Cup 1975/76, Second Qualifying Round |
| | | Great Harwood | – | Prescot Town | | 5:1 |
| |
FA Cup 1974/75, First Qualifying Round |
| | | Winsford United | – | Prescot Town | | 5:1 |
| |
FA Cup 1973/74, First Qualifying Round |
| | | Connah's Quay Nomads | – | Prescot Town | | 5:1 |
| |
FA Cup 1972/73, First Qualifying Round |
| | | Winsford United | – | Prescot Town | | 1:0 |
| |
FA Cup 1971/72, First Qualifying Round |
| | | Great Harwood | – | Prescot Town | | 7:1 |
| |
FA Cup 1970/71, Preliminary Round |
| | | Marine | – | Prescot Town | | 2:1 |
| |
FA Cup 1969/70, Preliminary Round |
| | | Prescot Town | – | Runcorn | | 1:6 |
| |
FA Cup 1968/69, Preliminary Round |
| | | Rhyl | – | Prescot Town | | 5:1 |
| |
FA Cup 1967/68, First Qualifying Round |
| | | Prescot Town | – | Stalybridge Celtic | | 0:1 * |
| |
FA Cup 1966/67, First Qualifying Round |
| | | Mossley | – | Prescot Town | | 6:2 |
| |
FA Cup 1965/66, First Qualifying Round |
| | | Prescot Town | – | Altrincham | | 1:2 |
| |
FA Cup 1964/65, First Qualifying Round |
| | | St Helens Town | – | Prescot Cables | | 4:1 |
| |
FA Cup 1963/64, First Qualifying Round |
| | | South Liverpool | – | Prescot Cables | | 3:0 |
| |
FA Cup 1962/63, First Qualifying Round |
| | | Ashton United | – | Prescot Cables | | 2:0 |
| |
FA Cup 1961/62, Second Qualifying Round |
| | | Prescot Cables | – | Wigan Athletic | | 1:3 * |
| |
FA Cup 1960/61, Preliminary Round |
| | | Wigan Athletic | – | Prescot Cables | | 2:0 |
| |
FA Cup 1959/60, First Round Proper |
| 14.11.1959 | | Darlington | – | Prescot Cables | | 4:0 |
| |
FA Cup 1958/59, Second Qualifying Round |
| | | Llandudno | – | Prescot Cables | | 5:4 |
| |
FA Cup 1957/58, First Round Proper |
| 16.11.1957 | | Hartlepools United | – | Prescot Cables | | 5:0 |
| |
FA Cup 1956/57, Preliminary Round |
| | | New Brighton | – | Prescot Cables | | 1:0 |
| |
FA Cup 1955/56, First Qualifying Round |
| | | Pwllheli & District | – | Prescot Cables | | 4:1 |
| |
FA Cup 1954/55, Preliminary Round |
| | | Pwllheli & District | – | Prescot Cables | | 7:0 |
| |
FA Cup 1953/54, Second Qualifying Round |
| | | Prescot Cables | – | Pwllheli & District | | 0:1 |
| |
FA Cup 1952/53, First Qualifying Round |
| | | Flint Town United | – | Prescot Cables | | 3:0 * |
| |
FA Cup 1951/52, Third Qualifying Round |
| | | Bangor City | – | Prescot Cables | | 1:0 |
| |
FA Cup 1950/51, First Qualifying Round |
| | | Skelmersdale United | – | Prescot Cables | | 6:2 |
| |
FA Cup 1949/50, First Qualifying Round |
| | | Bootle Athletic | – | Prescot Cables | | 2:1 |
| |
FA Cup 1948/49, Second Qualifying Round |
| | | Rhyl | – | Prescot Cables | | 2:1 |
| |
FA Cup 1947/48, Third Qualifying Round |
| | | Wigan Athletic | – | Prescot Cables | | 3:0 |
| |
FA Cup 1946/47, Third Qualifying Round |
| | | Haydock C&B Recreation | – | Prescot Cables | | 1:0 * |
| |
