FA Cup 2021/22, Third qualifying round |
 | 02.10.2021 |  | Spennymoor Town | – | Southport | | 0:0 |
| Spennymoor |
FA Cup 2021/22, Second qualifying round |
| 18.09.2021 | | Chorley | – | Southport | | 2:2 (0:2) |
| Chorley |
FA Cup 2020/21, Third Qualifying Round |
| 13.10.2020 | | Southport | – | South Shields | | 1:1,
pen. 2:4 |
| Southport |
FA Cup 2018/19, Second Round Proper |
| 02.12.2018 | | Tranmere Rovers | – | Southport | | 1:1 (1:0) |
| Birkenhead |
FA Cup 2016/17, First Round Proper |
| 07.11.2016 | | Southport | – | Fleetwood Town | | 0:0 |
| Southport |
FA Cup 2014/15, First Round Proper |
| 08.11.2014 | | Dagenham & Redbridge | – | Southport | | 0:0 |
| London |
FA Cup 2014/15, Fourth Qualifying Round |
| 28.10.2014 | | Southport | – | Tamworth | | 1:1 aet
(0:0, 1:1),
pen. 4:2 * |
| Southport |
FA Cup 2014/15, Fourth Qualifying Round |
| 25.10.2014 | | Tamworth | – | Southport | | 1:1 (1:0) |
| Tamworth |
FA Cup 2009/10, Third Qualifying Round |
| 10.10.2009 | | Alfreton Town | – | Southport | | 2:2 |
| |
FA Cup 2005/06, First Round Proper |
| 05.11.2005 | | Southport | – | Woking | | 1:1 (0:1) |
| Southport |
FA Cup 2001/02, Fourth Qualifying Round |
| | | Marine | – | Southport | | 1:1 (1:1) |
| |
FA Cup 2000/01, Fourth Qualifying Round |
| | | Doncaster Rovers | – | Southport | | 2:2 (0:0) |
| |
FA Cup 1999/00, Fourth Qualifying Round |
| | | Southport | – | Emley | | 1:1 (0:1) |
| |
FA Cup 1996/97, Fourth Qualifying Round |
| | | Spennymoor United | – | Southport | | 2:2 |
| |
FA Cup 1996/97, Second Qualifying Round |
| | | Southport | – | Emley | | 1:1 |
| |
FA Cup 1992/93, Fourth Qualifying Round |
| | | Barrow | – | Southport | | 0:0 |
| |
FA Cup 1992/93, First Qualifying Round |
| | | Southport | – | Buxton | | 0:0 |
| |
FA Cup 1986/87, Third Qualifying Round |
| | | Emley | – | Southport | | 4:4 aet * |
| |
FA Cup 1986/87, Third Qualifying Round |
| | | Southport | – | Emley | | 3:3 |
| |
FA Cup 1986/87, Second Qualifying Round |
| | | Lancaster City | – | Southport | | 1:1 |
| |
FA Cup 1986/87, First Qualifying Round |
| | | Garforth Town | – | Southport | | 1:1 aet * |
| |
FA Cup 1986/87, First Qualifying Round |
| | | Southport | – | Garforth Town | | 1:1 |
| |
FA Cup 1984/85, Second Qualifying Round |
| | | Southport | – | Alfreton Town | | 1:1 |
| |
FA Cup 1978/79, Fourth Qualifying Round |
| | | Northwich Victoria | – | Southport | | 0:0 |
| |
FA Cup 1977/78, First Round Proper |
| 26.11.1977 | | Southport | – | Runcorn | | 2:2 |
| |
FA Cup 1965/66, Third Round Proper |
| 22.01.1966 | | Southport | – | Ipswich Town | | 0:0 |
| |
FA Cup 1965/66, Second Round Proper |
| 04.12.1965 | | Southport | – | Stockport County | | 3:3 |
| |
FA Cup 1962/63, First Round Proper |
| 03.11.1962 | | Southport | – | Wrexham |  | 1:1 |
| |
FA Cup 1960/61, Second Round Proper |
| 26.11.1960 | | Bangor City | – | Southport | | 1:1 |
| |
FA Cup 1959/60, First Round Proper |
| 14.11.1959 | | Southport | – | Workington | | 2:2 |
| |
FA Cup 1956/57, First Round Proper |
| 17.11.1956 | | Southport | – | York City | | 0:0 |
| |
FA Cup 1955/56, Second Round Proper |
| 10.12.1955 | | Southport | – | Grimsby Town | | 0:0 |
| |
FA Cup 1953/54, Second Round Proper |
| 12.12.1953 | | Southport | – | Port Vale | | 1:1 |
| |
FA Cup 1951/52, Second Round Proper |
| 18.12.1951 | | Southport | – | Reading | | 1:1 aet * |
| |
FA Cup 1951/52, Second Round Proper |
| 15.12.1951 | | Reading | – | Southport | | 1:1 |
| |
FA Cup 1951/52, First Round Proper |
| 24.11.1951 | | Bangor City | – | Southport | | 2:2 |
| |
FA Cup 1950/51, First Round Proper |
| 25.11.1950 | | Lincoln City | – | Southport | | 1:1 |
| |
FA Cup 1949/50, Third Round Proper |
| 07.01.1950 | | Southport | – | Hull City | | 0:0 |
| |
FA Cup 1949/50, First Round Proper |
| 26.11.1949 | | Southport | – | Barrow | | 1:1 |
| |
FA Cup 1948/49, Second Round Proper |
| 11.12.1948 | | Southport | – | York City | | 2:2 |
| |
FA Cup 1947/48, First Round Proper |
| 29.11.1947 | | Hull City | – | Southport | | 1:1 |
| |
FA Cup 1938/39, Third Round Proper |
| 10.01.1939 | | Southport | – | Doncaster Rovers | | 1:1 |
| |
FA Cup 1938/39, First Round Proper |
| 26.11.1938 | | Scarborough | – | Southport | | 0:0 |
| |
FA Cup 1934/35, First Round Proper |
| 28.11.1934 | | New Brighton | – | Southport | | 1:1 aet * |
| |
FA Cup 1934/35, First Round Proper |
| 24.11.1934 | | Southport | – | New Brighton | | 1:1 |
| |
FA Cup 1932/33, First Round Proper |
| 26.11.1932 | | Southport | – | Nelson | | 3:3 |
| |
FA Cup 1931/32, Fourth Round Proper |
| 26.01.1932 | | Southport | – | Newcastle United | | 1:1 aet * |
| |
FA Cup 1931/32, Fourth Round Proper |
| 23.01.1932 | | Newcastle United | – | Southport | | 1:1 |
| |
FA Cup 1931/32, Third Round Proper |
| 09.01.1932 | | Barnsley | – | Southport | | 0:0 |
| |
FA Cup 1929/30, First Round Proper |
| 30.11.1929 | | Southport | – | Chesterfield | | 0:0 |
| |
FA Cup 1926/27, First Round Proper |
| 27.11.1926 | | Southport | – | Tranmere Rovers | | 1:1 |
| |
FA Cup 1921/22, First Round Proper |
| 07.01.1922 | | Blackburn Rovers | – | Southport | | 1:1 |
| |
FA Cup 1882/83, First Round |
| 21.10.1882 | | Liverpool Ramblers | – | Southport Central | | 1:1 |
| |
